Long-term effect of Helicobacter pylori eradication on plasma homocysteine in elderly patients with cobalamin deficiency

Campos Abreu Marino, Marilia; De Oliveira, Celso Affonso; Camargos Rocha, Andreia Maria; Aguiar Rocha, Gifone; Diogo Clementino, Nelma Cristina; Antunes, Leonardo Franca; Araüjo Oliveira, Ricardo; Sousa Martins, Almir; Lima Del Puerto, Helen; D'almeida, Vânia; Galdieri, Luciano; Pietra Pedroso, Enio Roberto; Demas Alvares Cabral, Monica Maria; Ferreira Nogueira, Ana Margarida Miguel; Magalhães Queiroz, Dulciene Maria
April 2007
Gut;Apr2007, Vol. 56 Issue 4, p469
Academic Journal
Background: Helicobacter pylori gastritis may lead to impairment of the production of pepsinogen and acid, which are essential to cobalamin absorption. In turn, cobalamin deficiency leads to hyperhomocysteinaemia, a risk factor for cardio and cerebrovascular diseases. Aim: To evaluate the effect of H pylori eradication on plasma homocysteine levels in elderly patients. Patients: Sixty-two H pylori-positive elderly patients with cobalamin deficiency were prospectively studied. Methods: Homocysteine and cobalamin concentrations were determined before, 6 and 12 months after H pylori eradication. Results: Corpus atrophy was observed in a few patients; otherwise, in most of them, the degree of corpus gastritis was moderate to severe. The initial homocysteine mean (SD) levels decreased from 41.0 (27.1) to 21.6 (10.1) µmol/l at the 6 month follow-up (p<0.001) and to 13.1 (3.8) µmol/l 12 months after H pylori eradication (p<0.001). Conversely, initial cobalamin mean levels increased from 145.5 (48.7) pmol/l to 209.8 (87.1) pmol/l and to 271.2 (140.8) pmol/l, 6 and 12 months after treatment, respectively (p<0.001 for both). Although the erythrocyte mean corpuscular volume was within reference intervals, it decreased significantly 6 (p = 0.002) and 12 (p<0.001) months after treatment. Conclusions: The results of the current study demonstrated that the eradication of H pylori in elderly patients with cobalamin deficiency is followed by increasing of cobalamin and decreasing of homocysteine blood levels.


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