In vivo single-photon emission computed tomography imaging of apoptosis in Crohn's disease and anti-tumour necrosis factor therapy

Watson, Alastair J. M.
April 2007
Gut;Apr2007, Vol. 56 Issue 4, p461
Academic Journal
The article reports on a study by J. M. H. Van der Brande and colleagues on evidence for the importance of apoptosis of lamina propria T cells in the action of infliximab. The researchers demonstrate that apoptosis in the intestine is increased compared with uninflammed intestine in two mouse models of colitis. They also show that infliximab induces more apoptosis in patients with Crohn's disease who respond than those who do not respond.


Related Articles

  • MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Sansom, Owen James; Zabkiewicz, Joanna; Bishop, Stefan Mark; Guy, Jackie; Bird, Adrian; Clarke, Alan Richard // Oncogene;10/16/2003, Vol. 22 Issue 46, p7130 

    MBD4 was originally identified through its methyl binding domain, but has more recently been characterized as a thymine DNA glycosylase that interacts with the mismatch repair (MMR) protein MLH1. In vivo, MBD4 functions to reduce the mutability of methyl-CpG sites in the genome and mice...

  • Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice. Yoshihara, K.; Yajima, Toshiki; Kubo, C.; Yoshikai, Y. // Gut;Mar2006, Vol. 55 Issue 3, p334 

    Background and aims: Interleukin (IL)-15 is a member of the IL-2 family, stimulating dendritic cells, natural killer (NK) cells, NK T cells and memory CD8+ T cells. IL-15 levels were elevated in the intestinal mucosa of inflammatory bowel diseases. Here we investigated the involvement of IL-15...

  • Intestinal Colonization of IL-2 Deficient Mice with Non- olitogenic B. vulgatus Prevents DC Maturation and T-Cell Polarization. Müller, Martina; Fink, Kerstin; Geisel, Julia; Kahl, Frauke; Jilge, Burghardt; Reimann, Jörg; Mach, Nicolas; Autenrieth, Ingo B.; Frick, Julia S. // PLoS ONE;2008, Vol. 3 Issue 6, p1 

    Background: IL-2 deficient (IL-2-1-) mice mono-colonized with E. coli mpk develop colitis whereas IL-2-1--mice monocolonized with B. vulgatus mpk do not and are even protected from E. coli mpk induced colitis. Methodology/Principal Findings: We investigated if mono-colonization with E. coli mpk...

  • Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model. Johansson, Malin E. V.; Gustafsson, Jenny K.; Sjöberg, Karolina E.; Petersson, Joel; Holm, Lena; Sjövall, Henrik; Hansson, Gunnar C. // PLoS ONE;2010, Vol. 5 Issue 8, p1 

    Background: Protection of the large intestine with its enormous amount of commensal bacteria is a challenge that became easier to understand when we recently could describe that colon has an inner attached mucus layer devoid of bacteria (Johansson et al. (2008) Proc. Natl. Acad. Sci. USA 105,...

  • Identification of a human intestinal myeloid cell subset that regulates gut homeostasis. Barman, Soumik; Hisako Kayama; Daisuke Okuzaki; Takayuki Ogino; Hideki Osawa; Hiroshi Matsuno; Tsunekazu Mizushima; Masaki Mori; Junichi Nishimura; Kiyoshi Takeda // International Immunology;Nov2016, Vol. 28 Issue 11, p533 

    Inappropriate activation of T helper (Th) cells, such as Th1 and Th17 cells, is implicated in the pathogenesis of chronic inflammatory disorders including ulcerative colitis (UC). CX3CR1high macrophages contribute to intestinal homeostasis through various mechanisms in mice. However, whether...

  • Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. Vlantis, Katerina; Wullaert, Andy; Sasaki, Yoshiteru; Schmidt-Supprian, Marc; Rajewsky, Klaus; Roskams, Tania; Pasparakis, Manolis // Journal of Clinical Investigation;Jul2011, Vol. 121 Issue 7, p2781 

    Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role of NF-κB in carcinogenesis. NF-κB activation in premalignant or cancer cells is believed to promote tumor development...

  • Inhibition of Pim-1 Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice. Shen, Yue-Ming; Zhao, Yan; Zeng, Ya; Yan, Lu; Chen, Bo-Lin; Leng, Ai-Min; Mu, Yi-Bin; Zhang, Gui-Ying // Digestive Diseases & Sciences;Jul2012, Vol. 57 Issue 7, p1822 

    Background: Pim-1 kinase is involved in the control of cell growth, differentiation and apoptosis. Recent evidence suggests that Pim kinases play a role in immune regulation and inflammation. However, the role of Pim-1 kinase in inflammatory bowel diseases (IBD) remains unclear. Aims: The aims...

  • Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Greenow, K R; Clarke, A R; Williams, G T; Jones, R // Oncogene;7/31/2014, Vol. 33 Issue 31, p4089 

    Chk1 is essential in maintaining genomic stability due to its role in cell cycle regulation. Several recent studies have indicated that the abrogation of checkpoints in tumourigenesis through the inhibition of Chk1 may be of therapeutic value. To further investigate the role of Chk1 in the mouse...

  • FADD: an endogenous inhibitor of RIP3-driven regulated necrosis. Galluzzi, Lorenzo; Kepp, Oliver; Kroemer, Guido // Cell Research;Oct2011, Vol. 21 Issue 10, p1383 

    The article presents a research study concerning the role of Fas-Associated protein with Death Domain (FADD) in the intestinal epithelium of mice. It notes that the findings of the study reveal that FADD which is a death domain-containing cytoplasmic adaptor protein functions as an endogenous...


Read the Article


Sign out of this library

Other Topics