TITLE

Hypertonic saline inhalation in cystic fibrosis—salt in the wound, or sweet success?

AUTHOR(S)
Enderby, Beth; Doull, Iolo
PUB. DATE
March 2007
SOURCE
Archives of Disease in Childhood;Mar2007, Vol. 92 Issue 3, p195
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the significance of hypertonic saline inhalation as an effective treatment in patients with cystic fibrosis. Several studies showed that hypertonic saline inhalation increases the airway surface layer (ASL) which lowers ASL volume of tonicity, decreasing lung disease. It covers that the optimal dose of the hypertonic saline should be given above 7 percent concentration twice a day.
ACCESSION #
24717266

 

Related Articles

  • Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function. Amin, Reshma; Subbarao, Padmaja; Jabar, Alisha; Balkovec, Susan; Jensen, Renee; Kerrigan, Shawn; Gustafsson, Per; Ratjen, Felix // Thorax;May2010, Vol. 65 Issue 5, p379 

    Background and aims Sensitive outcome measures to assess the efficacy of therapeutic interventions in patients with cystic fibrosis (CF) with mild lung disease are currently lacking. Our objective was to study the ability of the lung clearance index (LCI), a measure of ventilation inhomogeneity,...

  • Multiple-breath inert gas washout test and early cystic fibrosis lung disease. Aurora, P. // Thorax;May2010, Vol. 65 Issue 5, p373 

    The author reflects on multiple-breath inert gas washout (MBW) test and its use for monitoring the development of cystic fibrosis (CF) lung disease. He says that MBW, which can be performed using either a resident marker gas or an inhaled marker gas, describes the changes in exhaled tracer gas...

  • Inhaled Hypertonic Saline in Infants and Children Younger Than 6 Years With Cystic Fibrosis: The ISIS Randomized Controlled Trial. Rosenfeld, Margaret; Ratjen, Felix; Brumback, Lyndia; Daniel, Stephen; Rowbotham, Ron; McNamara, Sharon; Johnson, Robin; Kronmal, Richard; Davis, Stephanie D. // JAMA: Journal of the American Medical Association;6/6/2012, Vol. 307 Issue 21, p2269 

    The article focuses on the effect of inhaled hypertonic saline in patients younger than 6 years with cystic fibrosis (CF). CF lung disease includes airway infection, inflammation, obstruction, and structural lung damage. A trial was conducted from April 2009 to October 2011 at 30 CF care centers...

  • Hypertonic saline inhibits luminal sodium channels in respiratory epithelium. Hebestreit, Alexandra; Kersting, Ulrich; Hebestreit, Helge // European Journal of Applied Physiology;May2007, Vol. 100 Issue 2, p177 

    Physical exercise with increased ventilation leads to a considerable rise in water loss from the airways. The mechanisms underlying the regulation of transepithelial fluid transport necessary to compensate for these losses are unknown but may include changes in luminal ion channel conductance....

  • Mechanisms and applications of hypertonic saline. Elkins, Mark R.; Bye, Peter T. P. // Journal of the Royal Society of Medicine (Supplement);Jul2011, Vol. 104 Issue 1, pS2 

    The article presents an overview of the ways in which hypertonic saline, a strong sterile solution of water that can be inhaled as nebulized medication, can be used to treat patients with cystic fibrosis. A discussion of the mechanisms by which hypertonic saline affects the disease process of...

  • Cystic Fibrosis.  // Current Medical Literature: Respiratory Medicine;2006, Vol. 20 Issue 2, p40 

    The article presents abstracts of research related to cystic fibrosis. They include "A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis," "Exhaled nitric oxide is not reduced in infants with cystic fibrosis" and "Restoring airway surface liquid in cystic...

  • Comparison of Effects of 3 and 7% Hypertonic Saline Nebulization on Lung Function in Children with Cystic Fibrosis: A Double-Blind Randomized, Controlled Trial. Gupta, Sumita; Ahmed, Faizan; Lodha, Rakesh; Gupta, Y. K.; Kabra, Sushil K. // Journal of Tropical Pediatrics;Oct2012, Vol. 58 Issue 5, p375 

    Background: Beneficial effects of hypertonic saline on lung function in cystic fibrosis patients are well documented. However, the effects of various concentrations of hypertonic saline are not well studied. We, therefore, compared the effects of 3 and 7% hypertonic saline administered by...

  • Effects of hypertonic saline, alternate day and daily rhDNase on healthcare use, costs and outcomes in children with cystic fibrosis.  // Current Medical Literature: Respiratory Medicine;2003, Vol. 17 Issue 2, p56 

    Discusses the abstract of the article 'Effects of hypertonic saline, alternate day and daily rhDNase on healthcare use, costs and outcomes in children with cystic fibrosis,' by R. Suri, R. Grieve, C. Normand et al., published in the Number 57, 2002 issue of the 'Thorax' journal.

  • ALTERNATIVE MEDS UPDATE. Salt. Sego, Sherril // Clinical Advisor;Jun2013, Vol. 16 Issue 6, p91 

    The article discusses the efficacy of sodium chloride or salt therapy. It states that therapeutic methods on respiratory conditions include spending time in a natural salt cave, where salt acts as a mucolytic and decreases bronchial edema, and breathing aerosolized hypertonic salt water, where...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics