TITLE

Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma

AUTHOR(S)
Chua, Mei-Sze; Sun, Hongbo; Cheung, Siu T; Mason, Veronica; Higgins, John; Ross, Douglas T; Fan, Sheung T; So, Samuel
PUB. DATE
January 2007
SOURCE
Modern Pathology;Jan2007, Vol. 20 Issue 1, p76
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
24715954

 

Related Articles

  • NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression. Jin Zheng; Yan Li; Jiandong Yang; Qiang Liu; Ming Shi; Rui Zhang; Hengjun Shi; Qinyou Ren; Ji Ma; Hang Guo; Yurong Tao; Yan Xue; Ning Jiang; Libo Yao; Wenchao Liu // BMC Cancer;2011, Vol. 11 Issue 1, p251 

    Background: The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate of the disease. Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The role of CD24 and NDRG2 (N-myc downstream-regulated gene 2), a candidate...

  • N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review). YAN SONG; LILI CAO // Oncology Letters;2013, Vol. 6 Issue 6, p1539 

    N-myc downstream-regulated gene 1 (NDRG1) has been reported to be a multifunctional protein associated with carcinogenesis and tumor progression. However, the cellular function of NDRG1 remains elusive in human hepatocellular carcinoma (HCC). No NDRG1 expression is observed in normal liver...

  • NDRG2 down-regulation and CD24 up-regulation promote tumor aggravation and poor survival in patients with gallbladder carcinoma. Song, Shi-peng; Zhang, Sheng-bin; Liu, Rui; Yao, Li; Hao, Yu-qin; Liao, Ming-mei; Zhang, Yang-de; Li, Zhe-hai // Medical Oncology;Sep2012, Vol. 29 Issue 3, p1879 

    Recent studies have demonstrated that N-Myc downstream-regulated gene 2 (NDRG2) may reduce the metastatic potential of breast cancer and hepatocellular carcinoma cells by regulating the expression of CD24, which is expressed in a large variety of solid tumors. The aim of this study was to...

  • Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients. Nagai, Maria; Gerhard, Renê; Fregnani, José; Nonogaki, Suely; Rierger, Regina; Netto, Mário; Soares, Fernando // Breast Cancer Research & Treatment;Apr2011, Vol. 126 Issue 1, p1 

    An increasing number of studies have shown altered expression of secreted protein acidic and rich in cysteine (SPARC) and N-myc down-regulated gene (NDRG1) in several malignancies, including breast carcinoma; however, the role of these potential biomarkers in tumor development and progression is...

  • Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancer. Lorentzen, Anders; Lewinsky, Rikke H.; Bornholdt, Jette; Vogel, Lotte K.; Mitchelmore, Cathy // BMC Cancer;2011, Vol. 11 Issue 1, p1 

    Background: Several studies have shown that NDRG2 mRNA is down-regulated or undetectable in various human cancers and cancer cell-lines. Although the function of NDRG2 is currently unknown, high NDRG2 expression correlates with improved prognosis in high-grade gliomas, gastric cancer and...

  • Reduced N-Myc downstream-regulated gene 2 expression is associated with CD24 upregulation and poor prognosis in patients with lung adenocarcinoma. Wang, Haofei; Wang, Wujun; Wang, Xuelian; Cai, Kaican; Wu, Hua; Ju, Qun; Huang, Zhiyong; Gao, Xuhui // Medical Oncology;Dec2012, Vol. 29 Issue 5, p3162 

    N-Myc downstream-regulated gene 2 (NDRG2) has been demonstrated to influence the metastatic potential of hepatocellular carcinoma and breast cancer cells by regulating CD24 expression. The aim of this study was to investigate the roles of NDRG2 and CD24 in the clinical pathology of lung...

  • Expression of NDRG2 in human lung cancer and its correlation with prognosis. Li, Shu-jun; Wang, Wen-yong; Li, Bing; Chen, Bei; Zhang, Bo; Wang, Xin; Chen, Chang-sheng; Zhao, Qing-chuan; Shi, Hai; Yao, Libo // Medical Oncology;Mar2013, Vol. 30 Issue 1, p1 

    We had reported that N-myc downstream-regulated gene (NDRG2) regulates colorectal cancer, breast cancer, clear cell renal cell carcinoma, pancreatic cancer, thyroid cancer and esophageal squamous cell proliferation, development, and apoptosis. The goal of this study was to determine the...

  • Numb Promotes Cell Proliferation and Correlates with Poor Prognosis in Hepatocellular Carcinoma. Wu, Jian; Shen, Shun-Li; Chen, Bin; Nie, Jing; Peng, Bao-Gang // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Background: Numb is an evolutionary conserved protein that plays critical roles in cell fate determination, cell adhesion, cell migration and a number of signaling pathways, but evidence for a substantial involvement of Numb in HCC has remained unclear. The present study was aimed to investigate...

  • Low NDRG1 mRNA expression predicts a poor prognosis in neuroblastoma patients. Matsushita, Kohei; Uchida, Keiichi; Saigusa, Susumu; Ide, Shozo; Hashimoto, Kiyoshi; Koike, Yuhki; Otake, Kohei; Inoue, Mikihiro; Tanaka, Koji; Kusunoki, Masato // Pediatric Surgery International;Apr2013, Vol. 29 Issue 4, p363 

    Purpose: N-myc downstream regulated gene 1 (NDRG1) markedly reduces metastasis of numerous tumors. However, NDRG1's function in malignant tumors has not been fully determined. Therefore, we investigated the association of NDRG1 expression with clinical outcomes in neuroblastoma (NB) patients....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics