Characteristics of metabolically obese normal-weight (MONW) subjects

Conus, Florence; Rabasa-Lhoret, Rémi; Péronnet, François
February 2007
Applied Physiology, Nutrition & Metabolism;Feb2007, Vol. 32 Issue 1, p4
Academic Journal
The existence of a subgroup of normal-weight individuals displaying obesity-related phenotypic characteristics was first proposed in 1981. These individuals were identified as metabolically obese but normal weight (MONW). It was hypothesized that these individuals might be characterized by hyperinsulinemia and (or) insulin resistance, as well as by hypertriglyceridemia and high blood pressure despite having a body mass index (BMI) < 25 kg/m2. Such characteristics could confer upon MONW subjects a higher cardiovascular risk; however, scientific data on MONW subjects are scarce since only 9 publications are directly related to this topic. Despite differences in the criteria for identifying MONW subjects and the small number of subjects involved in most of these studies, their consistent results indicate that: (i) the prevalence of the MONW syndrome ranges between 5% and 45%, depending on the criteria used, age, BMI, and ethnicity; (ii) when compared with control subjects, MONW subjects display an altered insulin sensitivity, a higher abdominal and visceral adiposity, a more atherogenic lipid profile, a higher blood pressure, and a lower physical activity energy expenditure; and (iii) MONW subjects are at higher risks for type 2 diabetes and cardiovascular diseases.


Related Articles

  • Short-term effects of a non-dieting lifestyle intervention program on weight management, fitness, metabolic risk, and psychological well-being in obese premenopausal females with the metabolic syndrome. Carroll, Sean; Borkoles, Erika; Polman, Remco // Applied Physiology, Nutrition & Metabolism;Feb2007, Vol. 32 Issue 1, p125 

    Lifestyle modification has been widely acknowledged as the primary treatment for the metabolic syndrome (MetS). We examined the short-term effects of a non-dieting lifestyle intervention program, within the theoretical psychological framework of self-determination theory (SDT), on metabolic...

  • Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Odegaard, Justin I.; Ricardo-Gonzalez, Roberto R.; Goforth, Matthew H.; Morel, Christine R.; Subramanian, Vidya; Mukundan, Lata; Eagle, Alex Red; Vats, Divya; Brombacher, Frank; Ferrante, Anthony W.; Chawla, Ajay // Nature;6/28/2007, Vol. 447 Issue 7148, p1116 

    Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose tissue chronic overnutrition leads to macrophage infiltration, resulting in local inflammation that potentiates insulin resistance. For instance,...

  • Metabolic syndrome in youth: current issues and challenges. Huang, Terry T.-K.; Ball, Geoff D.C.; Franks, Paul W. // Applied Physiology, Nutrition & Metabolism;Feb2007, Vol. 32 Issue 1, p13 

    The current paper reviews the important issues and challenges facing children and adolescents with the metabolic syndrome (MetS). Studies suggest that the MetS and its risk components may be on the rise in children along with rising rates of obesity; however, further study remains warranted. The...

  • Metabolic syndrome: What it is, what to do about it.  // Journal of Business (10756124);2/7/2008 Supplement, Vol. 23, p7 

    The article offers information on metabolic syndrome. Metabolic syndrome is a group of disorders or conditions associated with the body's metabolism, including high blood pressure, insulin resistance, excess body weight and abnormal cholesterol levels. A combination of the conditions increases a...

  • Metabolic syndrome also found as risk for stroke.  // Cardiovascular Devices & Drugs;Jan2008, Vol. 14 Issue 1, p29 

    The article discusses information on a report published in the journal, "Stroke" regarding metabolic syndrome. The authors of the report concluded that metabolic syndrome constitutes a major public health burden as defined by its prevalence. They added that due to the increasing prevalence of...

  • Prevalence of the Metabolic Syndrome Defined by the International Diabetes Federation Among Adults in the U.S. Ford, Earl S. // Diabetes Care;Nov2005, Vol. 28 Issue 11, p2745 

    OBJECTIVE -- The International Diabetes Federation (IDF) has proposed a new definition of the metabolic syndrome that emphasizes central adiposity as determined by ethnic group--specific thresholds of waist circumference. The objective of this study was to estimate the prevalence of this...

  • Does treating obesity stabilize chronic kidney disease? Agnani, Sujata; Vachharajani, Vidula T.; Gupta, Rohit; Atray, Naveen K.; Vachharajani, Tushar J. // BMC Nephrology;2005, Vol. 6, p1 

    Background: Obesity is a growing health issue in the Western world. Obesity, as part of the metabolic syndrome adds to the morbidity and mortality. The incidence of diabetes and hypertension, two primary etiological factors for chronic renal failure, is significantly higher with obesity. We...

  • Metabolic Syndrome.  // Encyclopedic Reference of Molecular Pharmacology;2004, p582 

    An encyclopedia entry for the term "metabolic syndrome," is presented. It refers to a syndrome consisting of obesity, insulin resistance, hypertension, dyslipidemia and impaired glucose tolerance. The main component of the syndrome is obesity. The syndrome is frequently associated with type 2...

  • X PREVENTING SYNDROME. Roberts-Grey, Gina // American Fitness;Jul/Aug2008, Vol. 26 Issue 4, p20 

    The article discusses various issues concerning metabolic syndrome. According to Ryan Lafferty, spokesman for the American Heart Association, metabolic syndrome or Syndrome X, is the combination of obesity, hypercholesterolemia and hypertension linked by an underlying resistance to insulin. A...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics