TITLE

Synthesis of an 11-cis-locked biotinylated retinoid for sequestering 11-cis-retinoid binding proteins

AUTHOR(S)
Matsuda, Hiroko; Shenglong Zhang; Holmes, Andrea E.; Krane, Sonja; Itagaki, Yasuhiro; Nakanishi, Koji; Nesnas, Nasri
PUB. DATE
October 2006
SOURCE
Canadian Journal of Chemistry;Oct2006, Vol. 84 Issue 10, p1363
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The synthesis of a seven-membered ring locked analogue of 11-cis-retinol, tethered to a cross-linking moiety on C-15 and a lysine-extended biotin on the C-3, was accomplished for its utilization as a probe to fish out retinol binding proteins that may be involved in the reisomerization of retinal from all-trans to 11-cis in the visual cycle.
ACCESSION #
24715590

 

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