The MMRpro model accurately predicted the probability of carrying a cancer-susceptibility gene mutation for the Lynch syndrome

March 2007
ACP Journal Club;Mar/Apr2007, Vol. 146 Issue 2, p53
Academic Journal
The article reports on a study aimed to find out the accuracy of the MMRpro model in predicting the probability of carrying a deleterious mutation in DNA mismatch repair (MMR) genes in persons from families at high risk for the Lynch syndrome. The study was conducted on 279 patients who had colorectal or endometrial cancer and it found that the MMRpro model calculated an exact probability of carrying the mutation.


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