Providing AID to p53 mutagenesis

Takaishi, Shigeo; Wang, Timothy C.
April 2007
Nature Medicine;Apr2007, Vol. 13 Issue 4, p404
Academic Journal
The article discusses a study which presents a unique mechanism for p53 mutations in gastric cancer associated with Helicobacter pylori infection. The researchers found that the infection caused the aberrant expression of activation-induced cytidine deaminase, an enzyme that mediates antibody diversification.


Related Articles

  • How Useful Is the Detection Kit for Antibody to Helicobacter pylori in Urine (URINELISA) in Clinical Practice? Miwa, Hiroto; Hirose, Miyoko; Kikuchi, Shogo; Terai, Takeshi; Iwazaki, Ryozo; Kobayashi, Osamu; Takei, Yoshiyuki; Ogihara, Tatsuo; Sato, Nobuhiro // American Journal of Gastroenterology;Dec1999, Vol. 94 Issue 12, p3460 

    OBJECTIVE: Increased knowledge of the significance of Helicobacter pylori (H. pylori) infection in gastric disorders has accelerated the trend of screening patients with dyspepsia for its infection. Serological examination of antibody for H. pylori has been widely performed....

  • Seroepidemiology of Helicobacter pylori infection in Guadeloupe Weill, F.X.; Margeridon, S.; Broutet, N.; Le Hello, S.; Neyret, C.; Mégraud, F. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Sep2002, Vol. 96 Issue 5, p517 

    854 sera collected from blood donors in Guadeloupe were screened for Helicobacter pylori immunoglobulin G antibodies by a commercial enzyme-linked immunosorbent assay kit. The overall prevalence was 55 · 2%; it increased significantly with age from 36 · 1% at 18–19 years to 63 ·...

  • Using Macro-Arrays to Study Routes of Infection of Helicobacter pylori in Three Families. Raymond, Josette; Thiberge, Jean-Michel; Kalach, Nicolas; Bergeret, Michel; Dupont, Christophe; Labigne, Agnès; Dauga, Catherine // PLoS ONE;2008, Vol. 3 Issue 5, p1 

    Background: Analysis of the evolutionary dynamics of Helicobacter pylori allowed tracing the spread of infection through populations on different continents but transmission pathways between individual humans have not been clearly described. Materials and Methods: To investigate person-to-person...

  • Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India. Saxena, Ashish; Shukla, Sanket Kumar; Prasad, Kashi Nath; Ghoshal, Uday Chand // Indian Journal of Medical Research;Oct2012, Vol. 136 Issue 4, p664 

    Background & objectives: Mutations in the oncogene and tumour suppressor genes play an important role in carcinogenesis. We investigated the association of p53 and K-ras gene mutation and Helicobacter pylori infection in patients with gastric cancer (GC) and peptic ulcer disease (PUD) attending...

  • Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Jinxiong Wei; Noto, Jennifer M.; Zaika, Elena; Romero-Gallo, Judith; Piazuelo, Maria Blanca; Schneider, Barbara; El-Rifai, Wael; Correa, Pelayo; Peek, Richard M.; Zaika, Alexander I. // Gut;Jul2015, Vol. 64 Issue 7, p1040 

    Objective Infection with Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the stomach. Tumorigenic transformation of gastric epithelium induced by H. pylori is a highly complex process driven by an active interplay between bacterial virulence and host factors, many...

  • Campylobacter pylori Antibodies in Humans. Perez-Perez, Guillermo I.; Dworkin, Brad M.; Chodos, Joel E.; Blaser, Martin J. // Annals of Internal Medicine;7/1/88, Vol. 109 Issue 1, p11 

    Studies the diagnostic value of an enzyme-linked immunosorbent assay (ELISA) to measure serum antibodies in Campylobacter pylori (C. pylori) infection which are associated with active gastritis. Use of assays in determining the prevalence of C. pylori infection in healthy persons; Sensitivity...

  • Circulating free DNA and p53 antibodies in plasma of patients with ovarian epithelial cancers. Dobrzycka, B.; Terlikowski, S. J.; Kinalski, M.; Kowalczuk, O.; Niklinska, W.; Chyczewski, L. // Annals of Oncology;May2011, Vol. 22 Issue 5, p1133 

    Background: This study was conducted in order to evaluate the significance of circulating free DNA (CFDNA), blood plasma p53 antibodies (p53-Ab) and mutations of KRAS gene in the prognosis of ovarian epithelial cancers.Patients and methods: A total of 126 patients were included in this study....

  • Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. Sun, Xiao-Xin; Challagundla, Kishore B; Dai, Mu-Shui // EMBO Journal;2/1/2012, Vol. 31 Issue 3, p576 

    The ubiquitin (Ub)-proteasome system plays a pivotal role in the regulation of p53 protein stability and activity. p53 is ubiquitinated and destabilized by MDM2 and several other Ub E3s, whereas it is deubiquitinated and stabilized by Ub-specific protease (USP)7 and USP10. Here we show that the...

  • Co-twin Study of the Effect of Environment and Dietary Elements on Acquisition of Helicobacter pylori Infection. Malaty, Hoda M.; Graham, David Y.; Isaksson, Inger; Engstrand, Lars; Pedersen, Nancy L. // American Journal of Epidemiology;1998, Vol. 148 Issue 8, p793 

    The rate of Helicobacter pylori infection is inversely related to socioeconomic status, and childhood is thought to be the major acquisition period. The authors investigated the importance of childhood environment in the acquisition of H. pylori infection. A cross-sectional study was conducted...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics