Lung turns to AA (adenosine analogues) to dry out

Kreindler, James L.; Shapiro, Steven D.
April 2007
Nature Medicine;Apr2007, Vol. 13 Issue 4, p406
Academic Journal
The article discusses a study which showed that the levels of a simple nucleotide adenosine, regulate the activities of two ion channels: the epithelial sodium channel and the chloride channel, cystic fibrosis transmembrane conductance regulator. The adenosine regulation of the two channels established the balance between fluid secretion into the alveolus and fluid absorption from it.


Related Articles

  • Hormones increase mRNA of cyclic-nucleotide-gated cation channels in airway epithelia. Qiu, W.; Laheri, A.; Leung, Steve; Guggino, S. E. // Pflugers Archiv European Journal of Physiology;Nov2000, Vol. 441 Issue 1, p69 

    Previous studies have shown that the mRNA of cyclic-nucleotide-gated nonselective cation (CNG) channels is expressed in rat airway epithelia and that these channels contribute to sodium-mediated short-circuit currents in cultured rat tracheal epithelia. Patch-clamp studies from human A549 cells...

  • Nitric oxide has no beneficial effects on ion transport defects in cystic fibrosis human nasal epithelium. Rückes-Nilges, Claudia; Lindemann, H.; Klimek, Thorsten; Glanz, Hiltrud; Weber, Wolf-Michael // Pflugers Archiv European Journal of Physiology;Nov2000, Vol. 441 Issue 1, p133 

    Nitric oxide (NO) has been reported to activate Cl– secretion via the cystic fibrosis transmembrane conductance regulator (CFTR) and inhibit epithelial Na+ absorption mediated by amiloride-sensitive epithelial Na+ channels (ENaC). These ion transport systems are defective in cystic...

  • Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains. Moran, O.; Galietta, L. J. V.; Zegarra-Moran, O. // Cellular & Molecular Life Sciences;Feb2005, Vol. 62 Issue 4, p446 

    The use of substances that could activate the defective chloride channels of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) has been suggested as possible therapy for cystic fibrosis. Using epithelia formed by cells stably transfected with wildtype or mutant (G551D,...

  • CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Vergani, Paola; Lockless, Steve W.; Nairn, Angus C.; Gadsby, David C. // Nature;2/24/2005, Vol. 433 Issue 7028, p876 

    ABC (ATP-binding cassette) proteins constitute a large family of membrane proteins that actively transport a broad range of substrates. Cystic fibrosis transmembrane conductance regulator (CFTR), the protein dysfunctional in cystic fibrosis, is unique among ABC proteins in that its transmembrane...

  • Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. Lewis, Hal A.; Buchanan, Sean G.; Burley, Stephen K.; Conners, Kris; Dickey, Mark; Dorwart, Michael; Fowler, Richard; Xia Gao; Guggino, William B.; Hendrickson, Wayne A.; Hunt, John F.; Kearins, Margaret C.; Lorimer, Don; Maloney, Peter C.; Post, Kai W.; Rajashankar, Kanagalaghatta R.; Rutter, Marc E.; Sauder, J. Michael; Shriver, Stephanie // EMBO Journal;1/28/2004, Vol. 23 Issue 2, p282 

    Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding cassette (ABC) transporter that functions as a chloride channel. Nucleotide-binding domain 1 (NBD1), one of two ABC domains in CFTR, also contains sites for the predominant CF-causing mutation and, potentially, for...

  • Expression of Wild-Type CFTR Suppresses NF-κB-Driven Inflammatory Signalling. Hunter, Mairi J.; Treharne, Kate J.; Winter, Alexandra K.; Cassidy, Diane M.; Land, Stephen; Mehta, Anil // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Background: Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR) causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion transport. CF-inflammation provides one example but its pathogenesis remains controversial. Here, we tested the...

  • Rules of conduct for the cystic fibrosis anion channel. Wine, Jeffrey J // Nature Medicine;Jul2003, Vol. 9 Issue 7, p827 

    Improper ion balance resulting from defects in the ion channel CFTR underlies cystic fibrosis. Separate control mechanisms are now shown to regulate the flux of chloride and bicarbonate through this channel.

  • Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator. Skach, William R. // Kidney International;Mar2000, Vol. 57 Issue 3, p825 

    Defects in processing and trafficking of cystic fibrosis transmembrane conductance regulator. Cystic fibrosis (CF) is caused by inherited mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel expressed in epithelial...

  • KATP channelopathies in the pancreas. Remedi, Maria S.; Koster, Joseph C. // Pflugers Archiv European Journal of Physiology;Jul2010, Vol. 460 Issue 2, p307 

    Adenosine-triphosphate-sensitive potassium channels (KATP) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical activity in multiple tissues including the pancreatic β-cell. The critical involvement of KATP in insulin secretion is confirmed by the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics