Multiple Indomethacin-Induced Jejunal Ulcerations with Perforation: A Case Report with Histology

Risty, Gina M.; Najarian, Melissa M.; Shapiro, Stephen B.
April 2007
American Surgeon;Apr2007, Vol. 73 Issue 4, p344
Academic Journal
Gastric and duodenal inflammation and ulceration are well-known complications of nonsteroidal anti-inflammatory (NSAID) usage. However, small bowel ulceration and perforation secondary to NSAID use is uncommon and has rarely been reported in the literature. We describe a perforated jejunal ulcer that developed in a patient using indomethacin for treatment of ankylosing spondylitis. We performed a literature review of NSAID-induced small bowel injury and compared the histology of NSAID-related injury with more familiar causes of small bowel perforation.


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