TITLE

Preclinical evaluation of coronary vascular function after cardioplegia with HTK and different antioxidant additives

AUTHOR(S)
Schröder, Cornelia; Heintz, Anke; Pexa, Annette; Rauen, Ursula; Deussen, Andreas
PUB. DATE
May 2007
SOURCE
European Journal of Cardio-Thoracic Surgery;May2007, Vol. 31 Issue 5, p822
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract: Objective: Due to limited resources, improvement of preservation solutions is still of great importance in cardiac transplant surgery. New additives with antioxidant properties were tested with respect to coronary function of isolated rat hearts. Methods: Bretschneider HTK solution containing none or an antioxidant additive (deferoxamine, trolox or LK 616) was used for 8h cold cardioplegia. After reperfusion with Krebs-Henseleit buffer (KHB), we assessed vascular dilator capacity (bradykinin, adenosine triphosphate, reactive hyperemia), myocardial function (left ventricular developed pressure, heart rate, oxygen consumption) and release of biochemical markers (aspartate aminotransferase, creatine kinase, lactate dehydrogenase, troponin, adenosine). Results: Bradykinin- and adenosine triphosphate-induced vasodilations were largely reduced in hearts stored 8h in traditional HTK as compared to unstored controls. Storage in HTK+LK 616 significantly improved bradykinin-induced vasodilation. Vasodilation toward ATP was best preserved in hearts stored in HTK+deferoxamine. Deferoxamine and trolox, both improved reactive hyperaemic response during reperfusion. Left ventricular pressure development was significantly reduced after 8h cardioplegia, but no difference existed between different cardioplegia groups. Release of biochemical markers of tissue injury was similar in all cardioplegia groups. After storage in HTK+LK 616 (100μM), however, heart marker release was slightly augmented as compared to HTK. Conclusions: Despite similar myocardial function and marker release, coronary vascular function after cardioplegic storage may profit by addition of iron chelators (or antioxidants) to traditional HTK solution.
ACCESSION #
24611826

 

Related Articles

  • Clinical evaluation of a leucocyte-depleting blood cardioplegia filter (BC1B) for elective open-heart surgery. Suzuki, I.; Ogoshi, N.; Chiba, M.; Komatsu, T.; Moizumi, Y. // Perfusion;1998, Vol. 13 Issue 3, p205 

    Activation of leucocytes during extracorporeal circulation has attracted attention in recent years as a cause of reperfusion injury in open-heart surgery patients. In the present study, 40 adult patients undergoing elective open-heart surgery were randomized into two groups: 20 using the Pall...

  • Blood cardioplegia filtration. Martin, Juergen; Krause, Matthias; Benk, Christoph; Lutter, Georg; Siegenthaler, Michael; Beyersdorf, Friedhelm // Perfusion;Jan2003 Supplement, Vol. 18, p75 

    The introduction of blood cardioplegia has been proven to limit ischaemia and reperfusion injury in cardiac surgery. But the presence of activated neutrophils in the capillary bed may cause further damage. Leukocyte filters have been shown to be very effective in reducing the leukocytes in blood...

  • Normothermic Cardiac Surgery with Warm Blood Cardioplegia in Patient with Cold Agglutinins. Sang-Ho Cho; Dae Hyun Kim; Young Tae Kwak // Korean Journal of Thoracic & Cardiovascular Surgery;Apr2014, Vol. 47 Issue 2, p133 

    Cold agglutinins are predominately immunoglobulin M autoantibodies that react at cold temperatures with surface antigens on the red blood cell. This can lead to hemagglutination at low temperatures, followed by complement fixation and subsequent hemolysis on rewarming. Development of...

  • Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients. J. Boldt; Ch. Brosch; K. Röhm; M. Papsdorf; A. Mengistu // BJA: The British Journal of Anaesthesia;Apr2008, Vol. 100 Issue 4, p457 

    Background The effects of hydroxyethylstarch (HES) 130/0.4 6% and gelatin 4% on inflammation, endothelial integrity, and renal function after cardiac surgery were compared. Methods Sixty patients aged >80 yr undergoing cardiac surgery were randomized to receive gelatin (n=30) or HES 130/0.4...

  • Impact of a Large Hemodialysis Arteriovenous Fistula. Cetin, Levent; Sener, Erol; Kunt, Aysegul; Hidiroglu, Mete; Kucuker, Aslihan // Texas Heart Institute Journal;2012, Vol. 39 Issue 1, p122 

    Arteriovenous fistulae have a substantial impact on systemic hemodynamics, but their effect on cardiopulmonary bypass is not well understood. The left-to-right shunting of blood through an arteriovenous fistula can create flow problems during cardiopulmonary bypass. We present the case of a...

  • EuroSCORE: a systematic review of international performance. Gogbashian, A.; Sedrakyan, A.; Treasure, T. // European Journal of Cardio-Thoracic Surgery;May2004, Vol. 25 Issue 5, p695 

    The validity of the cardiac surgical scoring system, EuroSCORE, has been assessed by several individual cardiac centres within and outside Europe. We chose to assess the overall international performance by systematic review of peer-reviewed literature. There were six studies meeting our...

  • Unstable angina and non-ST segment elevation: surgical revascularization with different strategies. Onorati, Francesco; Feo, Marisa De; Mastroroberto, Pasquale; Virgilio, Antonio di; Esposito, Antonio; Polistena, Massimo; Renzulli, Attilio; Cotrufo, Maurizio // European Journal of Cardio-Thoracic Surgery;Jun2005, Vol. 27 Issue 6, p1043 

    Abstract: Objective: Unstable angina/non-ST elevation myocardial infarction (UA/NSTEMI) still causes significant hospital morbidity and mortality. We evaluated whether surgical outcome can be modified by different myocardial protection strategies. Methods: This was a prospective clinical study...

  • On-pump beating heart versus off-pump coronary artery bypass surgery—evidence of pump-induced myocardial injury. Rastan, Ardawan Julian; Bittner, Hartmuth Bruno; Gummert, Jan Fritz; Walther, Thomas; Schewick, Claudia V.; Girdauskas, Evaldes; Mohr, Friedrich Wilhelm // European Journal of Cardio-Thoracic Surgery;Jun2005, Vol. 27 Issue 6, p1057 

    Abstract: Objective: By maintaining native coronary blood flow in on-pump beating heart surgery (OnP-BH) and comparing with OPCAB strategy pump-related effects on myocardial injury and cardiac dysfunction could be specifically differentiated from ischemia/reperfusion-related consequences of...

  • 31P MRS of heart grafts provides metabolic markers of early dysfunction. Caus, Thierry; Kober, Frank; Mouly-Bandini, Annick; Riberi, Alberto; Métras, Dominique R.; Cozzone, Patrick J.; Bernard, Monique // European Journal of Cardio-Thoracic Surgery;Oct2005, Vol. 28 Issue 4, p576 

    Abstract: Objective: Early graft failure (EGF) is a life-threatening event still accounting for a significant percentage of early deaths after heart transplantation. We tested whether selected metabolic markers, including high-energy phosphate concentrations measured ex vivo in pre-transplant...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics