Hypertriglyceridemia: its etiology, effects and treatment

Yuan, George; Al-Shali, Khalid Z.; Hegele, Robert A.
April 2007
CMAJ: Canadian Medical Association Journal;4/10/2007, Vol. 176 Issue 8, p1113
Academic Journal
Elevated plasma triglyceride concentration is a common biochemical finding, but the evidence for the benefit of treating this lipid disturbance remains less robust than that for treating elevated low-density lipoprotein-cholesterol. Part of the difficulty in the provision of specific recommendations has been the frequent coexistence of elevated triglycerides with other conditions that affect cardiovascular disease risk, such as depressed high-density lipoprotein-cholesterol, obesity, metabolic syndrome, proinflammatory and prothrombotic biomarkers, and type 2 diabetes. Recent investigations of outcomes of cardiovascular disease when medications are used to reduce triglyceride levels suggest that, although a net benefit probably exists, both relative and absolute risk reductions seem underwhelming when compared with the benefit of reducing low-density lipoprotein-cholesterol levels with treatment. However, the totality of evidence suggests that elevated triglyceride levels likely contribute independently to increased risk of cardiovascular disease, although there is no consensus about appropriate target levels. Furthermore, severe hypertriglyceridemia is associated with an increased risk of acute pancreatitis, irrespective of its effect on risk of cardiovascular disease. We review the causes and classification of elevated triglyceride levels, the clinical manifestations of primary hypertriglyceridemia and the management of patients with elevated triglyceride levels.


Related Articles

  • The Combination of Elevated Triglycerides and Abnormal Fasting Glucose Increases Risk of Cerebral Infarction in Patients With Mild to Moderate Hypercholesterolemia: A Post Hoc Analysis of the MEGA Study. Nakagami, Tomoko; Nishimura, Rimei; Sone, Hirohito; Tajima, Naoko // Journal of Cardiovascular Pharmacology & Therapeutics;Mar2015, Vol. 20 Issue 2, p169 

    The article discusses a study on the combined effects of elevated triglycerides (TGs) and glucose on cardiovascular disease (CVD) in a post hoc analysis of large-scale Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study. Topics discussed include the...

  • Use of Plasmapheresis in Managing the Diagnostic Dilemma of Symptomatic Hypertriglyceridemia. Maher, Nigel Gordon; Ramaswamykanive, Hariharan // Case Reports in Gastrointestinal Medicine;2012, p1 

    We present a case study of a 29-year-old male who presented with abdominal pain typical for pancreatitis. Detailed history and investigations revealed that the cause of abdominal pain was secondary to the raised triglyceride levels. It was difficult to distinguish whether he had...

  • Ethinylestradiol/etonogestrel.  // Reactions Weekly;Mar2015, Vol. 1541 Issue 1, p124 

    An abstract of the article "Nuva ring-induced hypertriglyceridemia resulting in necrotizing pancreatitis," by A. P. Raghuwanshi and colleagues is presented.

  • PII-6. Straka, R. J.; Burkhardt, R. T.; Li, N.; Tsai, M. Y.; Peacock, J. M.; Stephenson, S. H.; Hopkins, P. M.; Arnett, D. K. // Clinical Pharmacology & Therapeutics;Feb2006, Vol. 79 Issue 2, pP37 

    Background: Recognizing the growing significance of triglycerides (TG) and cardiovascular risk, the purpose of the study was to examine factors regulating TG response to fenofibric acid (FA)-the active moiety of the PPAR-α agonist fenofibrate.Methods: Subjects >=18 years with normal renal...

  • Investigation and management of hypertriglyceridaemia. Ferns, G.; Keti, V.; Griffin, B. // Journal of Clinical Pathology;Nov2008, Vol. 61 Issue 11, p1174 

    While the precise definition of hypertriglyceridaemia remains contentious, the condition is becoming more common in western populations as the prevalence of obesity and diabetes mellitus rise. Although there is strong epidemiological evidence that hypertriglyceridaemia is an independent risk...

  • Effect of alirocumab on specific lipoprotein non-high-density lipoprotein cholesterol and subfractions as measured by the vertical auto profile method: analysis of 3 randomized trials versus placebo. Toth, Peter P.; Hamon, Sara C.; Jones, Steven R.; Martin, Seth S.; Joshi, Parag H.; Kulkarni, Krishnaji R.; Banerjee, Poulabi; Hanotin, Corinne; Roth, Eli M.; McKenney, James M. // Lipids in Health & Disease;2/13/2016, Vol. 15, p1 

    Background: The effect of alirocumab on potentially atherogenic lipoprotein subfractions was assessed in a post hoc analysis using the vertical auto profile (VAP) method. Methods: Patients from three Phase II studies with low-density lipoprotein cholesterol (LDL-C) ≥2.59 mmol/L (100 mg/dL)...

  • Lomitapide.  // Reactions Weekly;May2014, Vol. 1500 Issue 1, p25 

    An abstract of the article "Severe hypertriglyceridemia with pancreatitis: Thirteen years' treatment with lomitapide," by F. M. Sacks and colleagues is presented.

  • LIPID MANAGEMENT.  // Monthly Prescribing Reference;Jan2014, Vol. 30 Issue 1, p20 

    The article focuses on low-density lipoprotein-cholesterol (LDL-C) as the main goal of lipid management. Topics include Therapeutic Lifestyle Changes (TLC) as the first-line therapy and reserve drug therapy for higher risk patients, doing lipoprotein analysis for in case of coronary heart...

  • Primary Hypertriglyceridemia With Borderline High Cholesterol and Elevated Apolipoprotein B Concentrations. Vega, Gloria Lena; Grundy, Scott M. // JAMA: Journal of the American Medical Association;12/5/90, Vol. 264 Issue 21, p2759 

    Discusses a study which compared the efficacy of gemfibrozil and lovastatin therapy for primary hypertriglyceridemia. Background of the study population; Analysis of lipids, lipoproteins and apolipoprotein-B; Impact of lovastatin on cholesterol levels; Effect of gemfibrozil therapy on high...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics