TITLE

THE CANONICAL WNT SIGNALLING PATHWAY AN ITS APC PARTNER IN COLON CANCER DEVEOPMENT

AUTHOR(S)
Schneikert, Jean; Behrens, Jürgen
PUB. DATE
March 2007
SOURCE
Gut;Mar2007, Vol. 56 Issue 3, p417
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article explores the canonical Wnt signal transduction pathway in colorectal cancer. The canonical Wnt signaling cascades controls cell behavior by activating the transcriptional properties of Deoxyribonucleic Acid-binding proteins if the T cell factor/lymphoid enhancer factor-1 family. Several drugs, such as non-steroidal anti-inflammatory drugs, were established known to be effective in the treatment of colorectal cancer which turned out later to target the Wnt protein pathway.
ACCESSION #
24528577

 

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