Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection

Sebahat Ozdem; Mustafa Akcam; Aygen Yilmaz; Meral Gultekin; Reha Artan
April 2007
Digestive Diseases & Sciences;Apr2007, Vol. 52 Issue 4, p967
Academic Journal
Abstract  We investigated the biochemical markers of bone metabolism in children withHelicobacter pyloriinfection. Biochemical markers of bone metabolism and serum levels of vitamin B12, ferritin and estradiol were measured in 41H. pylori-positive (+) children (23 girls, 18 boys; aged 11.8±3 years). Serum levels of intact parathyroid hormone, ß-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly betweenH. pylori(+) andH. pylorinegative (−) children. Vitamin B12 levels were significantly decreased inH. pylori(+) compared toH. pylori(−) children.H. pyloriinfection was not accompanied by significant changes in markers of bone metabolism in children, although vitamin B12 levels were decreased. Further studies are required to clarify whetherH. pyloriinfection causes time-dependent changes in bone turnover markers during the long course of this inflammatory disease.


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