TITLE

See a pocket, block it

AUTHOR(S)
Moore, John P.; Dragic, Tatjana
PUB. DATE
October 1999
SOURCE
Nature;10/21/1999, Vol. 401 Issue 6755, p759
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Discusses a discovery that a cavity formed in the HIV-1 gp41 transmembrane glycoprotein can accommodate small, circular D-peptides that could prevent HIV-1 from fusing with and entering human cells. Block to production of T cells in the immunodeficiencies of AIDS; Prevention of the necessary intermolecular interactions that drive membrane fusion; Clinical trials on T-20.
ACCESSION #
2450455

 

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