TITLE

The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

AUTHOR(S)
Burzlaff, Nicolai I.; Rutledge, Peter J.
PUB. DATE
October 1999
SOURCE
Nature;10/14/1999, Vol. 401 Issue 6754, p721
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Describes the observation of the isopenicillin N synthase reaction in crystals by X-ray crystallography. Two-stage reaction sequence leading to penicillin; Challenge in protein crystallography; Development of a modified substrate that could interrupt the reaction cycle at the monocyclic stage.
ACCESSION #
2450422

 

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