TITLE

Donor age intensifies the early immune response after transplantation

AUTHOR(S)
Reutzel-Selke, A.; Jurisch, A.; Denecke, C.; Pascher, A.; Martins, P. N. A.; Keßler, H.; Tamura, A.; Utku, N.; Pratschke, J.; Neuhaus, P.; Tullius, S. G.
PUB. DATE
April 2007
SOURCE
Kidney International;Apr2007, Vol. 71 Issue 7, p629
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Increasing donor age is associated with reduced graft function. We wondered if donor age may not only affect intrinsic function but also alter the immune response of the recipient. Kidneys from young and old F-344 rats (3 vs 18 months) were transplanted into bilaterally nephrectomized young Lewis recipients and compared with age-matched controls (follow-up: 6 months). Renal function and structural changes were assessed serially in both native kidneys and allografts. Host alloreactivity, graft-infiltrating cells, and their inflammatory products were determined at intervals to examine the correlation of immune response and donor age. Functional and structural deterioration had advanced significantly in older allografts compared with age-matched native controls, whereas differences between young allografts and native controls of similar age were only minor. Changes in grafts from elderly rats were associated with a more intense host immune response early post-transplant (up to 1 month) reflected by significantly higher numbers of peripheral T and B cells, increased T-cell alloreactivity and modified cytokine patterns associated with elevated frequencies of intragraft dendritic cells, B cells, and CD31+ cells. By 6 months, recipients of young donor grafts produced comparable or more intense alloantigen-specific immune responses. Older donor grafts elicit a stronger immune response in the early period after transplantation.Kidney International (2007) 71, 629–636. doi:10.1038/sj.ki.5002098; published online 31 January 2007
ACCESSION #
24486820

 

Related Articles

  • T-cell alloimmunity and chronic allograft dysfunction. Safinia, Niloufar; Afzali, Behdad; Atalar, Kerem; Lombardi, Giovanna; Lechler, Robert I. // Kidney International Supplement;Dec2010 Supplement 119, Vol. 78, pS2 

    Solid organ transplantation is the standard treatment to improve both the quality of life and survival in patients with various end-stage organ diseases. The primary barrier against successful transplantation is recipient alloimmunity and the need to be maintained on immunosuppressive therapies...

  • Cell-Based Therapies in the Prevention of Solid Organ Transplant Rejection. Morelli, Adrian E.; Divito, Sherrie J. // American Journal of Immunology;2012, Vol. 8 Issue 2, p52 

    Problem statement: Organ transplantation is a life-saving and increasingly common procedure, as it often serves as the only treatment available for end-stage organ disease. Although the constant development of new and more effective immunosuppressive drugs has revolutionized the prevention and...

  • Immunological risk in recipients of kidney transplants from extended criteria donors. Diet, Carine; Audard, Vincent; Roudot-Thoraval, Françoise; Matignon, Marie; Lang, Philippe; Grimbert, Philippe // Nephrology Dialysis Transplantation;Aug2010, Vol. 25 Issue 8, p2745 

    Background. Determining if a kidney from a marginal donor is likely to elicit a strong and specific immune response, leading to an increased risk of acute rejection, is of importance in renal transplantation.

  • Prediction of chronic renal allograft dysfunction from evaluations of TGFÎ’1 and the renin-angiotensin system. Yamada, Kenichi; Hatakeyama, Emiko; Arita, Seiji; Sakamoto, Kaoru; Kashiwabara, Hidehiko; Hamaguchi, Kinichi // Clinical & Experimental Nephrology;Sep2003, Vol. 7 Issue 3, p238 

    Background. Growth factors, cytokines, and the renin-angiotensin system (RAS) are involved in chronic allograft dysfunction. However, it is unclear whether clinical evaluations of TGFÎ’1 and the RAS in longterm stable transplant patients can predict the development of chronic allograft...

  • High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response. Lihua Duan; Cong-Yi Wang; Jie Chen; Quan Gong; Ping Zhu; Fang Zheng; Zheng Tan; Feili Gong; Min Fang // Laboratory Investigation (00236837);Jan2011, Vol. 91 Issue 1, p43 

    Previously, we reported that extracellular high-mobility group box 1 (HMGB1) functions as an innate alarmin implicated in cardiac allograft acute rejection. We now present evidence suggesting that HMGB1 is pivotal in inducing interleukin-17 (IL-17)-producing alloreactive T cells by stimulating...

  • Tolerogenic dendritic cells and negative vaccination intransplantation: from rodents to clinical trials. Moreau, Aurélie; Varey, Emilie; Bériou, Gaëlle; Hill, Marcelo; Bouchet-Delbos, Laurence; Segovia, Mercedes; Cuturi, Maria-Cristina // Frontiers in Immunology;Aug2012, Vol. 3, p1 

    The use of immunosuppressive (IS) drugs to treat transplant recipients has markedly reduced the incidence of acute rejection and early graft loss. However, such treatments have numerous adverse side effects and fail to prevent chronic allograft dysfunction. In this context, therapies based on...

  • Hypoxia stimulus: An adaptive immune response during dendritic cell maturation. Rama, I.; Bruene, B.; Torras, J.; Koehl, R.; Cruzado, J. M.; Bestard, O.; Franquesa, M.; Lloberas, N.; Weigert, A.; Herrero-Fresneda, I.; Gulias, O.; Grinyó, J. M. // Kidney International;Apr2008, Vol. 73 Issue 7, p816 

    The ‘injury hypothesis’ in organ transplantation suggests that ischemia–reperfusion injury is involved in the adaptative alloimmune response. We previously found that a strong immune/inflammatory response was induced by ischemia during kidney transplantation in rats. We show...

  • Immunomodulation with dendritic cells and donor lymphocyte infusion converge to induce graft vs neuroblastoma reactions without GVHD after allogeneic bone marrow transplantation. Ash, S.; Stein, J.; Askenasy, N.; Yaniv, I. // British Journal of Cancer;11/9/2010, Vol. 103 Issue 10, p1597 

    Background:Mounting evidence points to the efficacy of donor lymphocyte infusion (DLI) and immunisation with tumour-pulsed dendritic cells (DC) in generating graft vs leukaemia reactions after allogeneic bone marrow transplantation (BMT). We assessed the efficacy of DLI and DC in generating...

  • Human dendritic cells process and present Listeria antigens for in vitro priming of autologous CD4+ T lymphocytes. Eppler, Elisabeth; Walch, Michael; Latinovic-Golic, Sonja; Dumrese, Claudia; Filgueira, Luis; Groscurth, Peter // Histochemistry & Cell Biology;Feb2005, Vol. 123 Issue 2, p169 

    The role of human dendritic cells (DC) in the immune response toward intracellularly growing Listeria was analyzed under in vitro conditions using several morphological and functional methods. DC incubated withListeria innocuaandL. monocytogenes, respectively, readily phagocytosed the bacteria....

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics