Effects of Aerosolized Rabies Virus Exposure on Bats and Mice
Related Articles
- The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose. Zosky, Graeme R.; Von Garnier, Christophe; Stumbles, Philip A.; Holt, Patrick G.; Sly, Peter D.; Turner, Debra J. // Respiratory Research;2004, Vol. 5, p15
Background: Considerable variation exists in the protocols used to induce hyperresponsiveness in murine models of allergic sensitisation. We examined the effect of varying the number of antigen exposures at challenge on the development of methacholine responsiveness in systemically sensitised...
- Second Generation Inactivated Eastern Equine Encephalitis Virus Vaccine Candidates Protect Mice against a Lethal Aerosol Challenge. Honnold, Shelley P.; Bakken, Russell R.; Fisher, Diana; Lind, Cathleen M.; Cohen, Jeffrey W.; Eccleston, Lori T.; Spurgers, Kevin B.; Maheshwari, Radha K.; Glass, Pamela J. // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1
Currently, there are no FDA-licensed vaccines or therapeutics for eastern equine encephalitis virus (EEEV) for human use. We recently developed several methods to inactivate CVEV1219, a chimeric live-attenuated eastern equine encephalitis virus (EEEV). Dosage and schedule studies were conducted...
- Comparison of the effectiveness of antibody and cell-mediated immunity against inhaled and instilled influenza virus challenge. Rivers, Katie; Bowen, Larry E.; Jin Gao; Kevin Yang; Trombley, John E.; Kyle Bohannon, J.; Eichelberger, Maryna C. // Virology Journal;2013, Vol. 10 Issue 1, p1
Background: To evaluate immunity against influenza, mouse challenge studies are typically performed by intranasal instillation of a virus suspension to anesthetized animals. This results in an unnatural environment in the lower respiratory tract during infection, and therefore there is some...
- Responses of mice to inoculation with low doses of a bat rabies virus variant. Ndaluka, Christina; Bowen, Richard // Archives of Virology;Jun2013, Vol. 158 Issue 6, p1355
Rabies is generally considered a fatal disease, yet neutralizing antibodies to rabies virus (RV) have frequently been found in sera from healthy, insectivorous bats, and mark-recapture studies have demonstrated bats that are still alive years after the first detection of anti-RV antibodies. To...
- Correction: Aerosols transmit prions to immunocompetent and immunodeficient mice. Haybaeck, Johannes; Heikenwalder, Mathias; Klevenz, Britta; Schwarz, Petra; Margalith, Ilan; Bridel, Claire; Mertz, Kirsten; Zirdum, Elizabeta; Petsch, Benjamin; Fuchs, Thomas J.; Stitz, Lothar; Aguzzi, Adriano // PLoS Pathogens;2/12/2016, Vol. 12 Issue 2, p1
A correction to the article "Aerosols Transmit Prions to Immunocompetent and Immunodeficient Mice" that was published in a 2011 issue, is presented.
- 7P COMBINATION OF CETUXIMAB WITH RADIOIMMUNOTHERAPY SIGNIFICANTLY ENHANCES THERAPEUTIC RESPONSE IN COLORECTAL CANCER. Vassileva, V.; Mazzantini, M.; Rajkumar, V.; Robson, M.; Badar, A.; Rashid, M.; Boxer, G.; Pedley, B. // Annals of Oncology;Nov2014, Vol. 25 Issue suppl_6, pvi3
We explored a novel approach of combining radioimmunotherapy (RIT), using a humanized 131I-labelled anti-CEA antibody (131I-huA5B7) with cetuximab in colorectal cancer (CRC). The human CRC cell lines, SW1222 and LS174T, were used for in vitro studies, and to generate subcutaneous and hepatic...
- Glycoprotein-mediated induction of apoptosis limits the spread of attenuated rabies viruses in the central nervous system of mice. Sarmento, Luciana; Xia-Qing Li; Howerth, Elizabeth; Jackson, Alan; Zhen Fu // Journal of NeuroVirology;Dec2005, Vol. 11 Issue 6, p571
Induction of apoptosis by rabies virus (RV) has been reported to be associated with the expression of the glycoprotein (G), but inversely correlated with pathogenicity. To further delineate the association between the expression of the G and the induction of apoptosis, recombinant RVs with...
- Caracterización molecular y biológica del virus de la Rabia que circula en zorrillos de México enfocado a la variante del gen de la fosfoproteÃna (P). Loza-Rubio, Elizabeth; Nadin-Davis, Susan A.; Morales Salinas, Elizabeth // Revista Mexicana de Ciencias Pecuarias;abr-jun2012, Vol. 3 Issue 2, p155
No abstract available.
- An inactivated recombinant rabies CVS-11 virus expressing two copies of the glycoprotein elicits a higher level of neutralizing antibodies and provides better protection in mice. Xue, Xiang-Hong; Zheng, Xue-Xing; Wang, Hua-Lei; Ma, Jin-Zhu; Li, Ling; Gai, Wei-Wei; Wang, Tie-Cheng; Yang, Song-Tao; Xia, Xian-Zhu // Virus Genes;Jun2014, Vol. 48 Issue 3, p411
The rabies virus (RABV) G protein is the primary contributor to the pathogenicity and protective immunity of RABV. In this study, we generated a recombinant rCVS-11-G strain containing two copies of the G protein derived from the pathogenic wild-type (wt) CVS-11 strain and based on its...