HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds

Kanaki, Katerina; Pergantis, Spiros A.
April 2007
Analytical & Bioanalytical Chemistry;Apr2007, Vol. 387 Issue 8, p2617
Academic Journal
Various toxicological and metabolic interactions have been reported to exist between arsenic and selenium. In the present study, synthetic seleno-arsenic compounds, potentially suitable for probing metabolic interactions between these two elements, were prepared and tentatively characterized by using high-performance liquid chromatography (HPLC)–electrospray tandem mass spectrometry and HPLC–inductively coupled plasma mass spectrometry. In analogy to the recently identified thio-arsenic species, which can be prepared from their corresponding oxo-arsenic species via reaction with H2S, the seleno-arsenic compounds were also derived from oxo-arsenic compounds via reaction with H2Se. [Figure not available: see fulltext.]


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