Harvesting viral proteins

Lucas, Alexandra; McFadden, Grant
November 1999
CMAJ: Canadian Medical Association Journal;11/02/99, Vol. 161 Issue 9, p1134
Academic Journal
Focuses on viral immunomodulatory proteins. How they are used in treating immune and inflammation-mediated diseases such as asthma and arthritis; Examples of such proteins including cytokines and serine proteinase inhibitors (serpins); History of the utilization of the proteins; Prospects for the viral technology.


Related Articles

  • Computational Study on the Inhibitor Binding Mode and Allosteric Regulation Mechanism in Hepatitis C Virus NS3/4A Protein. Xue, Weiwei; Yang, Ying; Wang, Xiaoting; Liu, Huanxiang; Yao, Xiaojun // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    HCV NS3/4A protein is an attractive therapeutic target responsible for harboring serine protease and RNA helicase activities during the viral replication. Small molecules binding at the interface between the protease and helicase domains can stabilize the closed conformation of the protein and...

  • Endopeptidase activity characterization of E. coli-derived infectious bursal disease virus protein 4 tubules. Chang, Gary Ro-Lin; Wang, Min-Ying; Liao, Jiahn-Haur; Hsiao, Yu-Ping; Lai, Su-Yuan // PEDS: Protein Engineering, Design & Selection;Nov2012, Vol. 25 Issue 11, p789 

    Viral protein 4 (VP4) is a serine protease that catalyzes the hydrolysis of polyprotein pVP2-VP4-VP3 of infectious bursal disease virus. In this report, the recombinant VP4 with a His-tag and three mutants (VP4-S652A, VP4-K692A and VP4-S652A.K692A) were expressed in Escherichia coli. Soluble VP4...

  • Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Induces Apoptosis Dependent on Its 3C-Like Serine Protease Activity. Ma, Zhitao; Wang, Yalan; Zhao, Haiyan; Xu, Ao-Tian; Wang, Yongqiang; Tang, Jun; Feng, Wen-hai // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease in pigs caused by PRRS virus (PRRSV). Although PRRSV infection-induced cell apoptosis has been established, the related viral protein is still unknown. Here, we reported that PRRSV nonstructural protein 4 (nsp4)...

  • Erratum to: Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity. Awang, Raja; Lappin, David; MacPherson, Alexandrea; Riggio, Marcello; Robertson, Douglas; Hodge, Penny; Ramage, Gordon; Culshaw, Shauna; Preshaw, Philip; Taylor, John; Nile, Christopher // Inflammation Research;Jan2015, Vol. 64 Issue 1, p83 

    A correction is presented to the article "Clinical associations between IL-17 family cytokines and periodontitis and potential differential roles for IL-17A and IL-17E in periodontal immunity," that was published in the previous issue of the periodical.

  • Detection of Serine Proteases Secreted by Lucilia sericata In vitro and During Treatment of a Chronic Leg Ulcer. Schmidtchen, Artur; Wolff, H�l�ne; Rydeng�rd, Victoria; Hansson, Carita // Acta Dermato-Venereologica;Jul2003, Vol. 83 Issue 4, p310 

    Discusses the detection of serine proteases secreted by lucilia sericata in vitro and during treatment of a chronic leg ulcer. Growth of larvae and collection of larval secretions; Assessment of proteases production.

  • Nuclear translocation of granzyme B in target cell apoptosis. Pinkoski, M J; Heibein, J A; Barry, M; Bleackley, R C // Cell Death & Differentiation;Jan2000, Vol. 7 Issue 1, p17 

    Granzyme B is the prototypic member of a family of serine proteases localized to the cytolytic granules of cytotoxic lymphocytes. Together with another granule protein, perforin, granzyme B is capable of inducing all aspects of apoptotic death in target cells. A number of granzyme B substrates...

  • The Bovine Basic Pancreatic Trypsin Inhibitor (Kunitz Inhibitor): A Milestone Protein. P. Ascenzi; A. Bocedi; M. Bolognesi; A. Spallarossa; M. Coletta; R. Cristofaro; E. Menegatti // Current Protein & Peptide Science;Jun2003, Vol. 4 Issue 3, p231 

    The pancreatic Kunitz inhibitor, also known as aprotinin, bovine basic pancreatic trypsin inhibitor (BPTI), and trypsin-kallikrein inhibitor, is one of the most extensively studied globular proteins. It has proved to be a particularly attractive and powerful tool for studying protein...

  • Human Kallikreins: Common Structural Features, Sequence Analysis and Evolution. Yousef, George M.; Diamandis, Eleftherios P. // Current Genomics;Feb2003, Vol. 4 Issue 2, p147 

    Kallikreins are a subgroup of serine proteases with diverse physiological functions. The human kallikrein gene family has now been fully characterized and includes 15 members tandemly located on chromosome 19q13.4 In this review, we discuss the common structural features of kallikreins at the...

  • Thrombin Receptor Antagonists, Recent Advances in PAR-1 Antagonist Development. Anderluh, M.; Dolenc, M. Sollner // Current Medicinal Chemistry;Jul2002, Vol. 9 Issue 13, p1229 

    The receptor for the serine protease thrombin, the protease-activated receptor-1 (PAR-1), has been recently characterized. Its key roles in thrombin-stimulated human platelet activation, vascular endothelial and smooth muscle proliferation, inflammatory responses and neurodegeneration suggest...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics