TITLE

Malignant B Cells From Patients With Primary Central Nervous System Lymphoma Express Stromal Cell-Derived Factor-1

AUTHOR(S)
Katherine Falkenhagen; Sarah Coupland; Timothy Chipps; Rita Braziel
PUB. DATE
April 2007
SOURCE
American Journal of Clinical Pathology;Apr2007, Vol. 127 Issue 4, p633
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Although the pathogenesis of primary central nervous system lymphoma (PCNSL) remains unclear, it is hypothesized that specific chemokine-chemokine receptor interactions may attract malignant B lymphocytes into the CNS. Formalin-fixed, paraffin-embedded brain biopsy specimens from 40 patients with PCNSL were immunostained by an indirect immunohistochemical method incorporating antigen retrieval to detect the presence of B-cell chemokines, stromal cell-derived factor-1 (SDF-1; CXCL12) and macrophage inflammatory protein-3α (MIP-3α, CCL20), and the SDF-1 receptor, CXCR4. To assist in phenotyping of SDF-1 + cells, specimens were also stained for CD20 (B cells). Positive staining for SDF-1 was identified in all PCNSL cases and in tonsil. In biopsy specimens, SDF-1 expression was localized to resident brain cells and, in 80% of specimens, CD20+ malignant lymphocytes. Tumor cells also stained positively for CXCR4. In contrast, although expression ofMIP-3α was detected in tonsil, no expression of this chemokine could be demonstrated in PCNSL biopsy specimens. Our observations raise the possibility of targeting the SDF-1-CXCR4 signaling pathway as a potential treatment for PCNSL.
ACCESSION #
24398300

 

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