Gains at the 1p36 Chromosomal Region Are Associated With Symptomatic Leptomeningeal Dissemination of Supratentorial Glioblastomas

Andrey Korshunov; Regina Sycheva; Andrey Golanov; Igor Pronin
April 2007
American Journal of Clinical Pathology;Apr2007, Vol. 127 Issue 4, p585
Academic Journal
Symptomatic craniospinal dissemination of glioblastomas is considered rare, and unambiguous pathologic or molecular predictors of tumor leptomeningeal spread remain to be defined. We performed molecular analysis of 8 glioblastomas with symptomatic leptomeningeal dissemination by using fluorescence in situ hybridization and array-based comparative genomic hybridization (array-CGH). The most frequently encountered alteration was gain of the 1p36 locus, which was found in all 8 samples examined. Array-CGH analysis of 3 available samples also disclosed numerous gains at the 1pter-p36.1 locus involving at least 3 DNA clones from this chromosomal region. Consequently, an analysis of 1p copy number status might be kept in mind as an additional tool for further predicting the clinical course of glioblastoma.


Related Articles

  • Genomic instability in a healthy elderly population: a pilot study of possible cytogenetic markers related to ageing. Mladinic, Marin; Kopjar, Nevenka; Milic, Mirta; Buljevic Dasovic, Andrea; Huzak, Miljenko; Zeljezic, Davor // Mutagenesis;Sep2010, Vol. 25 Issue 5, p455 

    Accumulation of DNA damage may play a significant role in the aetiology of the ageing process. Although genomic lesions increase the risk of cancer, many elderly individuals do not suffer from neoplasia in spite of their late age. We aimed to evaluate the rate of genome integrity impairment...

  • Poster presentations: 2. Cytogenetics.  // Journal of Medical Genetics;Sep2002 Supplement, Vol. 39, pS56 

    Discusses the abstract of the research paper entitled 'A rapid method for the preparation of DNA from large insert genomic clones for use in FISH experiments,' by Simon Holden, J.J. Cox and F.L. Raymond and presented during the British Human Genetics Conference at the University of York in...

  • Molecular cytogenetic characterization of Aegilops biuncialis and its use for the identification of 5 derived wheat — Aegilops biuncialis disomic addition lines. Schneider, Annamária; Linc, Gabriella; Molnár, István; Molnár-Láng, Márta; Schwarzacher, T. // Genome;Dec2005, Vol. 48 Issue 6, p1070 

    The aim of the experiments was to produce and identify different Triticum aestivum – Aegilops biuncialis disomic addition lines. To facilitate the exact identification of the Ae. biuncialis chromosomes in these Triticum aestivum – Ae. biuncialis disomic additions, it was necessary...

  • The Anatomy of a Chromosome. Stewart, Fiona // Ulster Medical Journal;2010, Vol. 79 Issue 3, p110 

    The article discusses a study on chromosomes using molecular genetic and cytogenic methods. It discusses the composition of chromosomes, the nomenclature for translocations, the number and arrangement of genes on chromosomes, the DNA structure and genetic mutations. The techniques used in...

  • Molecular cytogenetics: karyotype evolution, phylogenomics and future prospects. Robinson, T J; Yang, F // Heredity;Jan2012, Vol. 108 Issue 1, p1 

    An introduction is presented in which the editor discusses various reports within the issue on topics including one related to chromosomal rearrangements and genomic structural variation, cross-species fluorescence in situ hybridization (FISH) and genome analysis of chromosomal breakage.

  • Molecular cytogenetics of the genus Artemisia (Asteraceae, Anthemideae): fluorochrome banding and fluorescence in situ hybridization. I. Subgenus Seriphidium and related taxa. Torrell, M.; Cerbah, M.; Siljak-Yakovlev, S.; Vallès, J. // Plant Systematics & Evolution;Jun2003, Vol. 239 Issue 1/2, p141 

    The distributional pattern of AT- and GC-rich regions and the physical mapping of ribosomal DNA (location of 18S-5.8S-26S and 5S rDNA) in the chromosomes of seven Artemisia species have been established by means of fluorochrome banding and fluorescence in situ hybridization (FISH). This is the...

  • A new chromosome nomenclature system for oat ( Avena sativa L. and A. byzantina C. Koch) based on FISH analysis of monosomic lines. Sanz, M. J.; Jellen, E. N.; Loarce, Y.; Irigoyen, M. L.; Ferrer, E.; Fominaya, A. // Theoretical & Applied Genetics;Nov2010, Vol. 121 Issue 8, p1541 

    Fluorescent in situ hybridization (FISH) with multiple probes was used to analyze mitotic and meiotic chromosome spreads of Avena sativa cv 'Sun II' monosomic lines, and of A. byzantina cv 'Kanota' monosomic lines from spontaneous haploids. The probes used were A. strigosa pAs120a (a repetitive...

  • Strawberry genome sequencing may lead to better berries. Davis, Tom // Emerging Food R&D Report;Jun2012, Vol. 23 Issue 3, p2 

    The article discusses the results of the DNA sequencing of strawberry plant by an international team of researchers. The investigators have identified the genes that are critical for valuable horticultural traits such as, flavor, nutritional value and flowering time. Many base pairs of DNA in...

  • First Insights into the Large Genome of Epimedium sagittatum (Sieb. et Zucc) Maxim, a Chinese Traditional Medicinal Plant. Di Liu; Shao-Hua Zeng; Jian-Jun Chen; Yan-Jun Zhang; Gong Xiao; Lin-Yao Zhu; Ying Wang // International Journal of Molecular Sciences;Jul2013, Vol. 14 Issue 7, p13559 

    Epimedium sagittatum (Sieb. et Zucc) Maxim is a member of the Berberidaceae family of basal eudicot plants, widely distributed and used as a traditional medicinal plant in China for therapeutic effects on many diseases with a long history. Recent data shows that E. sagittatum has a relatively...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics