TITLE

Necrotizing Soft-Tissue Infections and Sepsis Caused by Vibrio vulnificus Compared with Those Caused by Aeromonas Species

AUTHOR(S)
Yao-Hung Tsai; Robert Wen-Wei Hsu; Tsung-Jen Huang; Wei-Hsiu Hsu; Kuo-Chin Huang; Yen-Yao Li; Kuo-Ti Peng
PUB. DATE
March 2007
SOURCE
Journal of Bone & Joint Surgery, American Volume;Mar2007, Vol. 89-A Issue 3, p631
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Vibrio and Aeromonas species, which can cause necrotizing fasciitis and primary septicemia, are members of the Vibrionaceae family and thrive in aquatic environments. Because the clinical symptoms and signs of necrotizing fasciitis and sepsis caused by these two bacteria are similar, the purposes of this study were to describe the clinical characteristics of Vibrio vulnificus and Aeromonas infections, to analyze the risk factors for death, and to compare the effects of surgical treatment on the outcome. Methods: The cases of thirty-two patients with necrotizing soft-tissue infections and sepsis caused by Vibrio vulnificus (seventeen patients) and Aeromonas species (fifteen patients) were retrospectively reviewed over a four-year period. Surgical débridement or immediate limb amputation was initially performed in all patients. Demographic data, underlying diseases, laboratory results, and clinical outcome were analyzed for each patient in both groups. Results: Six patients in the Vibrio vulnificus group and four patients in the Aeromonas group died. The patients who died had significantly lower serum albumin levels than did the patients who survived (p < 0.05). The patients with a combination of hepatic dysfunction and diabetes mellitus had a higher mortality rate than those with either hepatic disease or diabetes mellitus alone (p < 0.05). The patients with Vibrio vulnificus infections had a significantly lower systolic blood pressure at presentation (p = 0.006). The patients with Aeromonas infections who died had significantly lower white blood-cell counts (p = 0.03) with significantly fewer numbers of segmented white blood cells than those who died in the Vibrio vulnificus group (p = 0.01). Conclusions: The contact history of patients with a rapid onset of cellulitis can alert clinicians to a differential diagnosis of soft-tissue infection with Vibrio vulnificus (contact with seawater or raw seafood) or Aeromonas species (contact with fresh or brackish water, soil, or wood). Early fasciotomy and culture-directed antimicrobial therapy should be aggressively performed in those patients with hypotensive shock, leukopenia, severe hypoalbuminemia, and underlying chronic illness, especially a combination of hepatic dysfunction and diabetes mellitus.
ACCESSION #
24344865

 

Related Articles

  • Sepsis with Bullous Necrotizing Skin Lesions due to Vibrio vulnificus Acquired Through Recreational Activities in the Baltic Sea. Kuhnt-Lenz, K.; Krengel, S.; Fetscher, S.; Heer-Sonderhoff, A.; Solbach, W. // European Journal of Clinical Microbiology & Infectious Diseases;Jan2004, Vol. 23 Issue 1, p49 

    This report describes the case of a 59-year-old woman with a history of non-Hodgkin's lymphoma who developed bacteremia with Vibrio vulnificus. The patient had been swimming in the unusually warm Baltic Sea in the summer of 2002. She presented with symptoms of septicemia and severe bullous...

  • Vibrio vulnificus necrotizing fasciitis associated with acupuncture. Kotton, Yael; Soboh, Soboh; Bisharat, Naiel // Infectious Disease Reports;2015, Vol. 7 Issue 3, p46 

    Necrotizing fasciitis is a severe life-threatening infection of the deep subcutaneous tissues and fascia. Infection with Vibrio vulnificus, a halophilic Gram-negative bacillus found worldwide in warm coastal waters, can lead to severe complications, particularly among patients with chronic liver...

  • Vibrio vulnificus Infection: Diagnosis and Treatment. Bross, Michael H.; Soch, Kathleen; Morales, Robert; Mitchell, Rayford B. // American Family Physician;8/15/2007, Vol. 76 Issue 4, p539 

    Vibrio vulnificus infection is the leading cause of death related to seafood consumption in the United States. This virulent, gram-negative bacterium causes two distinct syndromes. The first is an overwhelming primary septicemia caused by consuming raw or undercooked seafood, particularly raw...

  • Clinical features of Vibrio vulnificus infections in the coastal areas of the Ariake Sea, Japan. Matsumoto, Kouichi; Ohshige, Kenji; Fujita, Naohiro; Tomita, Yukiko; Mitsumizo, Shinji; Nakashima, Mikio; Oishi, Hirotaka // Journal of Infection & Chemotherapy;Aug2010, Vol. 16 Issue 4, p272 

    Vibrio vulnificus infection can result in necrotizing fasciitis and sepsis and is associated with high mortality. Most patients infected with this microbe have liver dysfunction as an underlying disease. However, because of the sporadic nature of outbreaks and unidentified cases, extensive...

  • Isolation of Vibrio vulnificus from Seawater and Emerging Vibrio vulnificus Septicemia on Jeju Island. Keun Hwa Lee; Sang Taek Heo; Young Ree Kim; Ig-Chan Pang // Infection & Chemotherapy;Jun2014, Vol. 46 Issue 2, p106 

    Vibrio vulnificus is an opportunistic human pathogen, transmitted from seawater, raw oyster, and shellfish and responsible for severe septicemia. We studied V. vulnificus from surface seawater around Jeju Island between 2010 and 2011. In 2010, V. vulnificus was isolated and vulnificus septicemia...

  • Necrotising fasciitis caused by Vibrio vulnificus in a child without known risk factors. Chiu, Shun; Chiu, Cheng-Hsun; Jaing, Tang-Her; Chang, Kao-Jung; Lin, Tzou-Yien // European Journal of Pediatrics;2002, Vol. 161 Issue 8, p464 

    Presents a case report describing necrotizing fasciitis caused by Vibrio (V.) vulnificus in a child without pre-existing risk factors. Background on the organism; Other cases of V. vulnificus sepsis in children; Importance of the case report.

  • Vibrio vulnificus: an unusual mode of acquisition and novel use of rapid susceptibility testing. Partridge, D. G.; Townsend, R.; Larkin, S.; Parsons, H. K. // Journal of Clinical Pathology;Apr2009, Vol. 62 Issue 4, p18 

    Infection with Vibrio vulnificus is uncommon in Europe but is associated with necrotising wound infections and life-threatening septicaemia. This case is one of infection most likely to have been acquired from a thermal pool in Turkey without preceding exposure to seawater or shellfish. The...

  • Deferoxamine.  // Reactions Weekly;2/14/2009, Issue 1239, p13 

    The article describes the case of a 65-year-old woman who developed Vibrio vulnificus sepsis while receiving deferoxamine. The patient had a history of myelodysplastic syndrome, for which she received ongoing blood transfusions. The clinical course of the patient is discussed, as well as the...

  • In Vivo Efficacy of the Combination of Ciprofloxacin and Cefotaxime against Vibrio vulnificus Sepsis. Jang, Hee-Chang; Choi, Su-Mi; Kim, Hee Kyung; Kim, Sung-Eun; Kang, Seung-Ji; Park, Kyung-Hwa; Ryu, Phil Youl; Lee, Tae-Hoon; Kim, Young Ran; Rhee, Joon Haeng; Jung, Sook-In; Choy, Hyon E // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    Objectives: The invivo efficacy of a cefotaxime-ciprofloxacin combination against Vibrio vulnificus and the effects on rtxA1 expression of commonly used antibiotics are unknown. Methods: In vitro time-kill studies were performed to evaluate synergism. Female BALB/c mice were injected...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics