TITLE

Degradation and Remodeling of Small Intestinal Submucosa in Canine Achilles Tendon Repair

AUTHOR(S)
Gilbert, Thomas W.; Ann M. Stewart-Akers; Simmons-Byrd, Abby; Badylak, Stephen F.
PUB. DATE
March 2007
SOURCE
Journal of Bone & Joint Surgery, American Volume;Mar2007, Vol. 89-A Issue 3, p621
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Extracellular matrix derived from porcine small intestinal submucosa is used for the repair of musculo-tendinous tissues. Preclinical evaluation and clinical use have suggested that small intestinal submucosa extracellular matrix degrades rapidly after implantation and can be replaced by host tissue that is functionally and histologically similar to the normal tissue. Methods: The present study analyzed the temporal degradation of a ten-layer multilaminate device of small intestinal submucosa extracellular matrix used for the repair of canine Achilles tendon and examined the corresponding histological appearance of the remodeled tissue during the course of scaffold degradation. Devices were fabricated from small intestinal submucosa extracellular matrix labeled with 14C. The amount of 14C remaining in the remodeled graft was measured by liquid scintillation counting at three, seven, fourteen, twenty-eight, sixty, and ninety days after surgery. Blood, urine, feces, and other parenchymal tissues were also harvested to determine the fate of scaffold degradation products. Tissue specimens were prepared for routine histological analysis to examine the morphology of the remodeled graft at each time-point. Results: The small intestinal submucosa extracellular matrix graft degraded rapidly, with approximately 60% of the mass lost by one month after surgery, and the graft was completely resorbed by three months after surgery. The graft supported rapid cellular infiltration and host tissue ingrowth. By ninety days after surgery, the remodeled small intestinal submucosa extracellular matrix consisted of a dense collagenous tissue with organization, cellularity, and vascularity similar to that of normal tendon. Conclusions: Small intestinal submucosa extracellular matrix is rapidly degraded after implantation for the repair of a musculotendinous tissue in this canine Achilles tendon repair model and is replaced by the deposition and organization of host tissue that is histologically similar to that of normal tissue. Clinical Relevance: The present study provides insight into the degradation and remodeling of extracellular matrix derived from porcine small intestinal submucosa, a biologic scaffold that has been used clinically for musculotendinous applications.
ACCESSION #
24344864

 

Related Articles

  • Beckham to miss World Cup after injury. Wilson, Stephen // Adirondack Daily Enterprise;3/16/2010, Vol. 117 Issue 64, p10 

    The article reports on the surgery undergone by 34-year-old midfielder David Beckham for torn left Achilles' tendon, after he was injured while playing for Italian club AC Milan, which will make him miss the World Cup that begins in June 11, 2010 in South Africa.

  • Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis. Andersson, Gustav; Danielson, Patrik; Alfredson, Håkan; Forsgren, Sture // Knee Surgery, Sports Traumatology, Arthroscopy;Oct2007, Vol. 15 Issue 10, p1272 

    Ultrasound and Doppler examination has shown high blood flow-neovascularisation inside and outside the ventral Achilles tendon in chronic painful tendinosis, but not in pain-free normal Achilles tendons. In patients with Achilles tendinosis, injections with the sclerosing substance polidocanol,...

  • Cochrane in CORR: Surgical Interventions for Treating Acute Achilles Tendon Ruptures (Review). Mundi, Raman; Madden, Kim; Bhandari, Mohit // Clinical Orthopaedics & Related Research;Jun2014, Vol. 472 Issue 6, p1703 

    The article discusses review of surgical interventions for treating acute achilles tendon ruptures. Topics discussed include performing randomized and quasi-randomized trials for comparing surgical and non-surgical treatment of achilles tendon rupture and use of Medline database for gathering...

  • The Influence of Early Weight-Bearing Compared with Non-Weight-Bearing After Surgical Repair of the Achilles Tendon. Suchak, Amar A.; Bostick, Geoff P.; Beaupré, Lauren A.; Durand, D'Arcy C.; Jomha, Nadr M. // Journal of Bone & Joint Surgery, American Volume;Sep2008, Vol. 90-A Issue 9, p1876 

    Background: The optimal rehabilitation protocol after surgical repair of an Achilles tendon rupture has not been well defined. The objective of this randomized study was to compare the effect of early weight-bearing with that of non-weight-bearing on early postoperative recovery following repair...

  • What's New in Orthopaedic Research. Rodeo, Scott A.; Delos, Demetris; Weber, Alex; Xiaodong Ju; Cunningham, Matthew E.; Fortier, Lisa; Maher, Suzanne // Journal of Bone & Joint Surgery, American Volume;10/20/2010, Vol. 92-A Issue 14, p2491 

    The article presents several studies relating to orthopaedic medicine in the U.S. It includes the influence of the mechanical environment on tendon and ligament structure and function and the effects of mechanical stimulation on Achilles tendon healing. Also mentioned is the interface tissue...

  • INTERMEDIATE TO LONG-TERM RESULTS OF A TREATMENT PROTOCOL FOR CALCANEAL FRACTURE MALUNIONS. Clare, Michael P.; Lee III, William E.; Sanders, Roy W. // Journal of Bone & Joint Surgery, American Volume;May2005, Vol. 87-A Issue 5, p963 

    Background: Nonoperative management of displaced intra-articular calcaneal fractures may result in malunion affecting the function of both the ankle and the subtalar joint. The purpose of this study was to report the intermediate to long-term results of a treatment protocol for calcaneal...

  • Successful treatment of a fracture of a huge Achilles tendon ossification with autologous hamstring tendon graft and gastrocnemius fascia flap: a case report. Ishikura, Hisatoshi; Fukui, Naoshi; Takamure, Hiroshi; Ohashi, Satoru; Iwasawa, Mitsuyasu; Takagi, Kentaro; Horita, Ayako; Saito, Ikuo; Mori, Toshihito // BMC Musculoskeletal Disorders;11/24/2015, Vol. 16, p1 

    Background: Fracture of an ossified Achilles tendon is a rare entity, and no standard treatment has been established. This is the first report to describe the use of a hamstring tendon graft and gastrocnemius fascia flap for Achilles tendon reconstruction.Case Presentation:...

  • Augmented Compared with Nonaugmented Surgical Repair After Total Achilles Rupture: Results of a Prospective Randomized Trial with Thirteen or More Years of Follow-up. Heikkinen, Juuso; Lantto, Iikka; Flinkkilä, Tapio; Ohtonen, Pasi; Pajala, Ari; Siira, Pertti; Leppilahti, Juhana // Journal of Bone & Joint Surgery, American Volume;1/20/2016, Vol. 98 Issue 2, p85 

    Background: This prospective randomized trial with a mean fourteen-year follow-up compared simple end-to-end repair with fascial flap-augmented repair for acute Achilles tendon ruptures.Methods: From 1998 to 2001, sixty patients with acute Achilles tendon rupture were...

  • Get Well Soon.  // Theatre Bay Area;Feb2011, Vol. 36 Issue 2, p12 

    The article looks at injured performers, Dan Hoyle, who has been recovering from an operation involving a torn Achilles tendon, and Joan Baez, who got injured after falling from a tree house.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics