TITLE

Electroretinographic assessment and diagnostic reappraisal of children with visual dysfunction: a prospective study

AUTHOR(S)
Vedantham, Vasumathy; Jethani, Jithendra; Vijayalakshmi, Perumalsamy
PUB. DATE
March 2007
SOURCE
Indian Journal of Ophthalmology;Mar2007, Vol. 55 Issue 2, p113
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Purpose: To assess the presence or absence of a retinal cause of visual impairment using electroretinography (ERG) in children with no obvious discernable cause on ocular examination.Design: Prospective observational case series.Materials and Methods: A prospective study was carried out involving 120 children with the mean age 4.4+/-3.2 years with visual dysfunction. All children underwent ERG under general anesthesia using a special handheld mini-Ganzfeld (Kurbisfeld) dome.Results: Fifty-two (43.3%) children were male and 68 (56.7%) were female. The clinical diagnosis was as follows: Leber's congenital amaurosis (LCA) (n=47), achromatopsia (n=25), congenital stationary night blindness (CSNB) (n=9) and others (unclassifiable, n=39). The visual acuity ranged from perception of light (PL) to PL with projection in children with LCA. In the rest (n=73), some sort of visually guided behavior was discernable. Following ERG, a diagnostic reappraisal resulted as follows: LCA (n=49), achromatopsia (n=28), CSNB (n=4), cone-rod dystrophy (n=22), rod-cone degeneration (n=7), normal (n=8) and others (unclassifiable, n=2). Except for the two unclassifiable cases, ERG was successful in the diagnosis or exclusion of retinal dysfunction in the rest. By Pearson Chi-square test, there was a statistically significant association between the clinical and ERG diagnosis (P < 0.001).Conclusion: LCA was the commonest cause of visual dysfunction in our series. A statistically significant correlation between clinical and electrophysiological diagnosis was seen. ERG helped in firmly establishing the presence or absence of global retinal dysfunction in the majority (118/120) of pediatric patients with visual dysfunction.
ACCESSION #
24286234

 

Related Articles

  • Is there a dysfunction in the visual system of depressed patients? Fountoulakis, Konstantinos N.; Fotiou, Fotis; Iacovides, Apostolos; Kaprinis, George // Annals of General Psychiatry;2005, Vol. 4, p1 

    Background: The aim of the current study was to identify a possible locus of dysfunction in the visual system of depressed patients. Materials and Methods: Fifty Major Depressive patients aged 21-60 years and 15 age-matched controls took part in the study The diagnosis was obtained with the SCAN...

  • Establishing baseline rod electroretinogram values in achromatopsia and cone dystrophy. Wang, Isaac; Khan, Naheed; Branham, Kari; Wissinger, B.; Kohl, Susanne; Heckenlively, J. // Documenta Ophthalmologica;Dec2012, Vol. 125 Issue 3, p229 

    Purpose: To establish the normal range of values for rod-isolated b-wave amplitudes in achromatopsia and cone dystrophies. Methods: We reviewed charts of 112 patients with various types of cone dystrophy, and compared their standardized electroretinographic rod b-wave amplitudes with age-matched...

  • Cerebral visual dysfunction in prematurely born children attending mainstream school. Macintyre-Béon, Catriona; Young, David; Dutton, Gordon; Mitchell, Kate; Simpson, Judith; Loffler, Gunter; Bowman, Richard; Hamilton, Ruth // Documenta Ophthalmologica;Oct2013, Vol. 127 Issue 2, p89 

    Purpose: Although premature birth is recognised as a cause of cerebral visual impairment (CVI), which can include cerebral visual dysfunction (CVD), the incidence and nature of CVD in prematurely born children is not known. Methods: A prospective, controlled investigation was undertaken of...

  • Toe Walking. Accardo, Pasquale; Whitman, Barbara // Clinical Pediatrics;Aug1989, Vol. 28 Issue 8, p347 

    Toe walking unassociated with an autistic disorder or cerebral palsy generally has been considered a normal infant gait. The incidence of toe walking in various diagnostic subgroups of 799 developmentally disabled children presenting to a tertiary-level multidisciplinary assessment clinic was...

  • Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial. Falsini, Benedetto; Chiaretti, Antonio; Rizzo, Daniela; Piccardi, Marco; Ruggiero, Antonio; Manni, Luigi; Soligo, Marzia; Dickmann, Anna; Federici, Matteo; Salerni, Annabella; Timelli, Laura; Guglielmi, Gaspare; Lazzareschi, Ilaria; Caldarelli, Massimo; Galli-Resta, Lucia; Colosimo, Cesare; Riccardi, Riccardo // Brain: A Journal of Neurology;2/1/2016, Vol. 139 Issue 2, p404 

    Paediatric optic pathway gliomas are low-grade brain tumours characterized by slow progression and invalidating visual loss. Presently there is no strategy to prevent visual loss in this kind of tumour. This study evaluated the effects of nerve growth factor administration in protecting visual...

  • Stereotyped Movements Among Children Who Are Visually Impaired. Gal, Eynat; Dyck, Murray J. // Journal of Visual Impairment & Blindness;Dec2009, Vol. 103 Issue 11, p754 

    Does the severity of visual impairment affect the prevalence and severity of stereotyped movements? In this study, children who were blind or had low vision, half of whom had intellectual disabilities, were assessed. The results revealed that blindness and global delays were associated with more...

  • Prevalencia de las disfunciones en los movimientos sacádicos, habilidades perceptuales visuales e integración visomotora en niños emétropes entre seis y siete años de estratos 1 y 2 de la ciudad de Bogotá. DURÁN, SANDRA; MARTÍNEZ GARAY, CATALINA; CAMACHO MONTOYA, MARCELA // Ciencia y Tecnología para la Salud Visual y Ocular;jul-dic2013, Vol. 11 Issue 2, p13 

    Objective: to determine the prevalence of dysfunctions in saccadic movements, visual perceptual skills and visual-motor integration in emmetropic children between the ages of six and seven from socio-economic levels 1 and 2 in Bogota. This study is part of the macroproject Influence of visual...

  • Neurodevelopmental Outcome in Children with Periventricular Leukomalacia. Rešić, Biserka; Tomasović, Maja; Kuzmanić-Šamija, Radenka; Lozić, Marin; Rešić, Jasminka; Solak, Mirsala // Collegium Antropologicum;Jan2008 Supplement 1, Vol. 32, p143 

    The purpose of this study was to question the correlation of different grades of periventricular leukomalacia (PVL) and subsequent neurodevelopmental outcome. In a prospective study we followed 52 preterm infants. Infants were divided into three groups according to their cranial ultrasound...

  • Impaired Visual Recognition Memory Predicts Alzheimer's Disease in Amnestic Mild Cognitive Impairment. Didic, Mira; Felician, Olivier; Barbeau, Emmanuel J.; Mancini, Julien; Latger-Florence, Caroline; Tramoni, Eve; Ceccaldi, Mathieu // Dementia & Geriatric Cognitive Disorders;May2013, Vol. 35 Issue 5/6, p291 

    Background: In the common form of Alzheimer's disease (AD), neurofibrillary tangles, which are associated with cognitive dysfunction, initially develop in the anterior subhippocampal (perirhinal/entorhinal) cortex before reaching the hippocampus. This area plays a key role in visual recognition...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics