Thyroid Arterial Embolization to Treat Graves' Disease

Zhao, W.; Gao, B. -L.; Yang, H. -Y.; Li, H.; Song, D. -P.; Xiang, S. -T.; Shen, J.
February 2007
Acta Radiologica;Feb2007, Vol. 48 Issue 2, p186
Academic Journal
Purpose: To prospectively investigate the effect of thyroid arterial embolization on hyperthyroid Graves' disease in selected patients. Material and Methods: Twenty-eight patients with hyperthyroidism caused by Graves' disease were enrolled to undergo thyroid arterial embolization and followed up for 12-22 months. Twenty-two patients had three thyroid arteries embolized and six patients two arteries. Serum thyroid hormone, thyroid-stimulating hormone (TSH), and autoimmune function were tested before and after embolization in all patients. Results: Of 28 patients, 22 (78.6%) became euthyroid, five improved (17.8%), and one had temporary improvement followed by recurrence (3.6%). No serious complications occurred. Compared with the pre-embolization values, serum concentrations of thyroid hormone increased temporarily on day 3 post-embolization, dropped substantially after 1 and 2 months, and returned to nearly normal at 6 and 12 months post-embolization. TSH dropped on day 3, increased after 1 and 2 months, and returned to normal after 6 and 12 months. Thyroid antibodies TGAb and TMAb declined on day 3 to normal range, rose after 1 month, dropped to normal again after 2 months, and were slightly increased at 6 and 12 months follow-up. Conclusion: Thyroid arterial embolization may be an effective approach for patients with hyperthyroidism caused by Graves' disease.


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