Magnetic Resonance Imaging with Liver-Specific Contrast Agent in Primary Amyloidosis and Intrahepatic Cholestasis

MØller, J. M.; Santoni-Rugiu, E.; Chabanova, E.; Løgager, V.; Hansen, A. B.; Thomsen, H. S.
February 2007
Acta Radiologica;Feb2007, Vol. 48 Issue 2, p145
Academic Journal
Magnetic resonance imaging (MRI) findings in hepatic amyloidosis are not well defined. Here, we report on a patient with renal failure caused by primary amyloidosis (AL type) who developed jaundice. Ultrasound and computed tomography were normal except for some ascites. MRI with oral manganese-containing contrast agent revealed several focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. No extrahepatic bile obstructions were found. Liver biopsy showed severe intraportal, vascular, and parenchymal amyloidosis causing severe cholestasis and atrophy of hepatocytes.


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