Sequence-activity relationships guide directed evolution

Pelletier, Joelle N; Lortie, Robert
March 2007
Nature Biotechnology;Mar2007, Vol. 25 Issue 3, p297
Academic Journal
The article reports on a new method for in vitro evolution that integrates computational analysis and experimental screening. This approach incorporates a protein sequence activity relationship algorithm which can be useful for evolving proteins with novel properties. The approach addresses the challenging synthesis of the dihydroxyheptanoate side chain of atorvastatin.


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