Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Wang, Zack Z; Au, Patrick; Tong Chen; Ying Shao; Daheron, Laurence M; Hao Bai; Arzigian, Melanie; Fukumura, Dai; Jain, Rakesh K; Scadden, David T
March 2007
Nature Biotechnology;Mar2007, Vol. 25 Issue 3, p317
Academic Journal
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.


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