TITLE

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

AUTHOR(S)
Wang, Zack Z; Au, Patrick; Tong Chen; Ying Shao; Daheron, Laurence M; Hao Bai; Arzigian, Melanie; Fukumura, Dai; Jain, Rakesh K; Scadden, David T
PUB. DATE
March 2007
SOURCE
Nature Biotechnology;Mar2007, Vol. 25 Issue 3, p317
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.
ACCESSION #
24279307

 

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