TITLE

Precise DNA placement and stretching in electrode gaps using electric fields in a microfluidic system

AUTHOR(S)
Dukkipati, Venkat Ram; Pang, Stella W.
PUB. DATE
February 2007
SOURCE
Applied Physics Letters;2/19/2007, Vol. 90 Issue 8, p083901
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Control over the placement of stretched deoxyribonucleic acid (DNA) molecules in a microfluidic system is a critical requirement for molecular nanotechnology. A technique is developed where a large number of DNA molecules can be immobilized specifically at one end to the electrode tip and stretched in a microchannel using high frequency ac fields. λ-DNA molecules are immobilized and stretched using 100 kHz ac fields in a 100 μm wide and 75 μm deep Si microchannel. Using a floating electrode in between two biased electrodes, stretched T2 DNA molecules are immobilized across a 5 μm wide electrode gap by electric field and hydrodynamic flow.
ACCESSION #
24257490

 

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