Malignant Nonfunctioning Endocrine Tumors of the Pancreas: Predictive Factors for Survival after Surgical Treatment

Jun Chul Chung; Dong Wook Choi; Sung Ho Jo; Jin Seok Heo; Seong Ho Choi; Yong Il Kim
March 2007
World Journal of Surgery;Mar2007, Vol. 31 Issue 3, p579
Academic Journal
There are scant studies that have analyzed the prognostic factors for malignant nonfunctioning endocrine tumors of the pancreas. We identified the predictive factors associated with long-term survival after surgical resection for malignant nonfunctioning endocrine tumors. Among the 25 patients seen at our hospital with a diagnosis of malignant nonfunctioning endocrine tumor, a review was performed on 22 of these patients who were surgically treated at our institution over the last 10 years. The following factors were evaluated for disease-specific mortality: age, gender, tumor location, tumor size, histological differentiation, status of the resection margin, and status of lymph node involvement. Tumor recurrence was noted in 9 cases (40.9%) among the 22 operated patients. Of the 9 recurrent cases, 7 patients (77.8%) had liver metastases. The median follow-up period was 24.8 (range: 3.7–121.4) months. The overall actuarial 1-, 2- and 5-year survival rates were 84.1%, 72.5%, and 52.8%, respectively. The factor shown to have a favorable independent prognostic significance was a negative resection margin (odds ratio = 19.44, 95% confidence interval = 1.22–310.54, P = 0.036). Definitive surgical resection of the primary tumor was a predictor of long-term survival after surgical resection for malignant nonfunctioning endocrine tumor.


Related Articles

  • DIAGNOSTIC DIFFICULTIES IN INSULINOMAS. THE IMPORTANCE OF ENDOSCOPIC ULTRASONOGRAPHY. Spiroiu, Cristina; Mazilu, Adina; Jinga, Mariana; Mihai, Ana Maria; Ranetti, A. E. // Acta Endocrinologica (1841-0987);Jun-Mar2006, Vol. 2 Issue 1, p95 

    Insulinoma is the most common endocrine tumor of the pancreas. The diagnosis suspicion is usually based on clinical symptoms and is confirmed by biochemical tests. Because the majority of insulinomas have a small size, the real problem is the localization of these tumors before surgery. We...

  • Somatostatin-Receptor Scintigraphy in the Management of Gastroenteropancreatic Tumors. Krausz, Yodphat; Bar-Ziv, Jacob; De Jong, Rolf B. J.; Ish-Shalom, Sophia; Chisin, Roland; Shibley, Nazeeh; Glaser, Benjamin // American Journal of Gastroenterology;Jan1998, Vol. 93 Issue 1, p66 

    Objective: This study evaluates the diagnostic and therapeutic implications of somatostatin-receptor scintigraphy in the management of patients with proven or high clinical suspicion of gastroenteropancreatic endocrine tumors. Methods: Forty-one patients were studied by planar and tomographic...

  • Diagnosis and Minimally Invasive Resection of an Insulinoma: Report of an Unusual Case and Review of the Literature. Gutelius, Bruce J.; Korytkowski, Mary T.; Carty, Sally E.; Hamad, Giselle G. // American Surgeon;May2007, Vol. 73 Issue 5, p520 

    Insulinomas are rare endocrine tumors that are usually diagnosed by inappropriate elevations in insulin and C-peptide during hypoglycemia. We report a case of a surgically confirmed insulinoma diagnosed by a mild elevation in proinsulin with suppressed insulin and C-peptide at the time of...

  • Insulinoma: A Case Report. Gowrishankar; Srimurthy, K. R.; Babu, Narendra; Balaji, Dhiraj; Kumar, Anjala; Ramesh, S. // Journal of Indian Association of Pediatric Surgeons;Jul-Sep2007, Vol. 12 Issue 3, p179 

    Background: Insulinomas are relatively rare pediatric endocrine neoplasms. Its small size, malignant potential, and the possibility of multiple tumors make localization and management, challenging and controversial. A thorough knowledge of the signs, symptoms, and clinical manifestation of this...

  • Nuclear Ploidy Is an Indicator of Malignancy Endocrine Pancreatic Tumor. Dubova, E.; Podgornova, M.; Shchyogolev, A. // Bulletin of Experimental Biology & Medicine;Feb2010, Vol. 149 Issue 2, p236 

    Comparative morphometric and densitometric studies of cell nuclei in endocrine tumors of various differentiation degree and endocrinocytes of Langerhans islet in the adjacent pancreatic tissue were carried out. Index of proliferative activity, aneuploidy coefficient, and histogram of nuclear DNA...

  • Vasoactive Intestinal Peptide-Receptor Imaging for the Localization of Intestinal Adenocarcinomas and Endocrine Tumors. Virgolini, Irene; Raderer, Markus; Kurtaran, Amir; Angelberger, Peter; Banyai, Susanne; Yang, Qiong; Li, Shuren; Banyai, Martin; Pidlich, Johann; Niederle, Bruno; Scheithauer, Werner // New England Journal of Medicine;10/27/94, Vol. 331 Issue 17, p1116 

    Background: Intestinal adenocarcinomas and various endocrine tumors express large numbers of high-affinity receptors for vasoactive intestinal peptide (VIP). We have evaluated the usefulness of scanning with VIP labeled with iodine-123 for tumor localization in patients with gastrointestinal...

  • Surgery for a gastroenteropancreatic neuroendocrine tumor (GEPNET) in multiple endocrine neoplasia type 1. Hanazaki, Kazuhiro; Sakurai, Akihiro; Munekage, Masaya; Ichikawa, Kengo; Namikawa, Tsutomu; Okabayashi, Takehiro; Imamura, Masayuki // Surgery Today;Mar2013, Vol. 43 Issue 3, p229 

    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited endocrine tumor syndrome characterized by tumor development in various endocrine organs such as the parathyroid, endocrine pancreas, anterior pituitary and adrenal cortex. The first extensive database for Asian...

  • EARLY RESULTS OF PANCREATODUODENECTOMY IN ONE HUNDRED CONSECUTIVE PATIENTS WITH MASS IN HEAD OF PANCREAS AND PERIAMPULLARY TUMORS. Wojciech Krasnodębski, Ireneusz; Słodkowski, Maciej; Jankowski, Mieczysław; Pertkiewicz, Marek; Cebulski, Włodzimierz; Petsch, Bronisław; Dąbrowski, Bohdan; Chaber, Andrzej; Pawłowski, Waldemar // Polish Surgery / Chirurgia Polska;2006 Supplement, Vol. 8, p18 

    Background: An assessment of the immediate results of the radical surgical treatment of tumors of the pancreatic head. Material and methods: This study comprised of one hundred consecutive patients (52 M; 48 F) who underwent a pancreatoduodenectomy between 1998 and 2003. Whipple's procedure was...

  • Early Detection of Pancreatic Glucagonoma. Haga, Yoshio; Yanagi, Hidetaka; Urata, Jouji; Inada, Masayuki; Shimada, Shinya; Nitahata, Nagomu; Tanimura, Masanori // American Journal of Gastroenterology;Dec1995, Vol. 90 Issue 12, p2216 

    Glucagonoma is a rare islet cell tumor of pancreas. Only 122 proven cases have been reported in the English literature so far. Diagnosis of glucagonoma has usually been delayed. The average size of clinically detected glucagonomas was 5.8 cm, and 54.7% of them exhibited metastasis. We describe...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics