TITLE

Extended Resections of Liver Metastases from Colorectal Cancer

AUTHOR(S)
Jonas, S.; Thelen, A.; Benckert, C.; Spinelli, A.; Sammain, S.; Neumann, U.; Rudolph, B.; Neuhaus, P.
PUB. DATE
March 2007
SOURCE
World Journal of Surgery;Mar2007, Vol. 31 Issue 3, p511
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Indications for resection of liver metastases from colorectal cancer and surgical strategies are still under debate. We have retrospectively reviewed the outcome of 660 patients after 685 liver resections for metastases of colorectal cancer in our institution from 1988 to 2004. All surviving patients have a minimum follow-up period of 1 year. The longest follow-up in these patients is 16 years. Three different time periods of 5 to 6 years each were analyzed. The 30- and 60-day mortality rates were 1.5% ( n = 10) and 2.2 % ( n = 15), respectively. The rate of formally curative (R0) resections was 84%. Five-year survival rates in all patients and in patients after R0 resection were 37% and 42%, respectively. If only resections from 1999 to 2004 were considered, 5-year survival in patients after R0 resection was 50%. In a multivariate analysis, surgical radicality, ligamental lymph node involvement, number of liver metastases, and time period, in which the liver resection had been performed, were independent prognostic parameters. Outcome after liver resection for metastases from colorectal cancer has constantly improved. A formally curative resection is the most relevant prognostic parameter. Number of liver metastases and, in the few patients concerned, lymph node infiltration of the hepatoduodenal ligament, were further prognostic parameters.
ACCESSION #
24240890

 

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