TITLE

Association of Neural Inflammation with Hyperalgesia Following Spinal Nerve Ligation

AUTHOR(S)
Znaor, Ljubo; Lovric, Sanja; Hogan, Quinn; Sapunar, Damir
PUB. DATE
February 2007
SOURCE
Croatian Medical Journal;2007, Vol. 48 Issue 1, p35
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
24235884

 

Related Articles

  • Fluoxetine, a selective serotonin reuptake inhibitor modulates inflammatory and neuropathic pain in the rat. Pal Singh, Vijay; Jain, Naveen K.; Kulkarni, S. K. // Inflammopharmacology;2002, Vol. 9 Issue 3, p219 

    The clinical usefulness of classical tricyclic antidepressants has been indicated in a variety of neuropathic pain. The role of selective serotonin reuptake inhibitors (SSRIs) is, however, controversial in pain control. The present study was aimed at evaluating the efficacy of an SSRI,...

  • Cytokine inhibition and time-related influence of inflammatory stimuli on the hyperalgesia induced by the nucleus pulposus. Souza Grava, André; Ferrari, Luiz; Defino, Helton // European Spine Journal;Mar2012, Vol. 21 Issue 3, p537 

    Introduction: The symptoms of lumbar disc herniation, such as low back pain and sciatica, have been associated with local release of cytokines following the inflammatory process induced by the contact of the nucleus pulposus (NP) with the spinal nerve. Material and methods: Using an animal...

  • Spinal Manipulative Therapy Depresses Hyperalgesia and Abnormal Expression of c-Fos and PKCγ in the Dorsal Horn of the Spinal Cord in Rats With Lumbar Intervertebral Foramen Inflammation. Xue-Jun Song; Xue-Song Song; Rupert, Ronald L. // Journal of Chiropractic Education (Association of Chiropractic C;Spring2008, Vol. 22 Issue 1, p77 

    Introduction: The authors have recently shown that Activator-assisted spinal manipulative therapy (SMT) significantly reduces pain and hyperalgesia following intervertebral foramen (IVF) inflammation in rats. This study further examined effects of SMT on IVF inflammation-induced expression of...

  • Inhibition of the morphine-induced rewarding effect by direct activation of spinal protein kinase C in mice. Kousei Oe; Narita, Minoru; Imai, Satoshi; Shibasaki, Masahiro; Kubota, Chiharu; Kasukawa, Akiko; Hamaguchi, Mami; Yajima, Yoshinori; Yamazaki, Mitsuaki; Suzuki, Tsutomu // Psychopharmacology;2004, Vol. 177 Issue 1/2, p55 

    Rationale: We previously demonstrated that the morphine-induced rewarding effect was attenuated under a neuropathic pain-like state following partial sciatic nerve ligation in rodents. Furthermore, the up-regulation of protein kinase C (PKC) activity in the spinal cord is considered to be the...

  • Loss of nerve: a molecular approach to better treatment of chronic pain. Friedrich, M.J. // JAMA: Journal of the American Medical Association;1/12/2000, Vol. 283 Issue 2, p187 

    Focuses on a molecular neosurgical approach that selectively target sensory nerves, in the treatment of chronic pain. Use of immunotoxins to make selective immunolesions in nerve pathways; Reduction in thermal hyperalgesia and mechanical allodynia associated with persistent neuropathic pain...

  • Sildenafil induces hyperalgesia via activation of the NO-cGMP pathway in the rat neuropathic pain model. Patil, C. S.; Padi, S. V.; Singh, V. P.; Kulkarni, S. K. // Inflammopharmacology;Mar2006, Vol. 14 Issue 1/2, p22 

    Persistent stimulation of nociceptors and C-fibers by tissue injury causes hyperalgesia and allodynia by sensitization of nociceptors and facilitation of synaptic transmission in the spinal cord. The important participant in the inflammatory response of injured peripheral nerve may be nitric...

  • Role of Endocannabinoids in Neuron-Glial Crosstalk. Luongo, Livio; Palazzo, Enza; de Novellis, Vito; Maione, Sabatino // Open Pain Journal;2010 Special Issue 1, p29 

    Evidence shows bidirectional crosstalk between neurons and glia, suggesting that glia play an active role in synaptic plasticity leading to chronic pain. Importantly, gliosis has been implicated in the development and maintenance of hyperalgesia or allodynia following chronic inflammation or...

  • Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Pineda-Farias, Jorge Baruch; Barragán-Iglesias, Paulino; Loeza-Alcocer, Emanuel; Torres-López, Jorge E.; Rocha-González, Héctor Isaac; Pérez-Severiano, Francisca; Rodolfo Delgado-Lezama; Granados-Soto, Vinicio // Molecular Pain;Jul2015, Vol. 11 Issue 1, p1 

    Background: Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies suggest that CaCCs family members bestrophin-1 and anoctamin-1 are...

  • Gene transfer to interfere with TNFa signaling in neuropathic pain. Hao, S; Mata, M; Glorioso, J C; Fink, D J // Gene Therapy;Jul2007, Vol. 14 Issue 13, p1010 

    We examined the role of spinal tumor necrosis factor-alpha (TNFa) in neuropathic pain of peripheral nerve origin. Two weeks after selective L5 spinal nerve ligation (SNL), rats exhibiting mechanical allodynia and thermal hyperalgesia showed a marked increase in full-length membrane-associated...

  • Spinal manipulation reduces pain and hyperalgesia after lumbar intervertebral foramen inflammation in the rat. Wyatt, Lawrence H. // Journal of the American Chiropractic Association;Mar2006, Vol. 43 Issue 2, p9 

    The article reviews the course study "Spinal manipulation reduces pain and hyperalgesia after lumbar intervertebral foramen inflammation in the rat."

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics