The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension

Bernard, Nathalie; Girouard, Joël; Forest, Jean-Claude; Giguère, Yves
March 2007
Journal of Human Genetics;Mar2007, Vol. 52 Issue 3, p244
Academic Journal
Dyslipidemia and insulin resistance contribute to the endothelial cell dysfunction in hypertensive disorders of pregnancy (HDP) and increase the long-term risk of cardiovascular disease (CVD). The genes linking susceptibility to gestational hypertension (GH) and/or preeclampsia (PE) to the long-term risk of CVD are still unknown. We evaluated the potential association between 14 polymorphisms from six genes involved in lipid metabolism and insulin action and the risk of HDP: namely the lipoprotein lipase ( LPL), hepatic lipase ( LIPC), hormone sensitive lipase ( LIPE), cholesteryl ester transfer protein ( CETP), ApoCIII and ApoE gene polymorphisms. Overall, 169 women with HDP [proteinuria (PE) and gestational hypertension without proteinuria (GH)] and 169 controls matched for age and year of delivery were genotyped. Homozygosity of the −514T allele of the −514C > T polymorphism ( LIPC gene) decreased the risk of GH (OR = 0.17, CI95: 0.02–0.76), while there were more −60G carriers of the −60C > G LIPE gene polymorphism (OR = 3.51, CI95:1.02–12.10) among GH cases, but not in PE cases. The common ApoCIII two-locus −482CC/3238CC genotype was lower in women with GH compared with controls (OR = 0.53, CI95: 0.3–0.9). The combined frequency of at-risk genotypes was higher in cases of GH compared with controls [one at-risk genotype: OR = 3.38 (95% CI: 0.48–41.8); two or more at-risk genotypes: OR = 7.14 (95% CI: 1.21–92.3, P = 0.01)], suggesting a gene-dose effect. We conclude that the combined effect of LIPC, LIPE and ApoCIII gene polymorphisms may increase the likelihood of GH, but seemingly not of PE.


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