TITLE

Analysis of the inflammatory response in endovascular treatment of aortic aneurysms

AUTHOR(S)
Gabriel, Edmo Atique; Locali, Rafael Fagionato; Romano, Carla Cristina; Duarte, Alberto José da Silva; Palma, José Honório; Buffolo, Enio
PUB. DATE
March 2007
SOURCE
European Journal of Cardio-Thoracic Surgery;Mar2007, Vol. 31 Issue 3, p406
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract: Objective: The objective of this study is to evaluate the inflammatory response caused by endovascular stents in the treatment of aortic aneurysms. Methods: Twenty-five patients underwent endovascular stent treatment from March through December 2005. The evolution of mediators (sedimentation velocity, C reactive protein, interleukin-6, interleukin-8, tumor necrosis factor-alpha, intercellular adhesion molecule-1, l-selectin), inflammatory cells (leukocytes, lymphocytes, platelets), serum creatinine and body temperature within preoperative period and in the following postoperative periods — 1, 6, 24 and 48h, 7 days, 1–3 months, was analyzed. In order to achieve statistic significance, Friedman test and Wilcoxon test were used, with index of significance of 5% (p <0.05). Results: Peak values of sedimentation velocity, C reactive protein and interleukin-6 were observed at 7 days (p <0.0001), 48h (p <0.0001) and 24h (p <0.0001), respectively. Tumor necrosis factor-alpha and interleukin-8 did not show statistically significant variability during the entire follow-up. In terms of intercellular adhesion molecule-1 and l-selectin, their expressive values were found in late phase of follow-up, although without statistical significance. Elevation of leukocytes count occurred in premature phase of follow-up (p <0.0001), while lymphocyte and platelet count occurred in a late phase of follow-up (p <0.0001). Serum levels of creatinine did not show significant variability during follow-up. The period between 24 and 48h corresponded to major frequency for fever (p <0.0001). Conclusion: Individual mediators analysis and inflammatory cells demonstrated variability of their values during postoperative follow-up. This could help in the analysis of the inflammatory response evolution caused by endovascular stent treatment for aortic aneurysms in premature and late phases after implantation of the vascular prosthesis.
ACCESSION #
24141305

 

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