TITLE

Pathogenesis and therapy of psoriasis

AUTHOR(S)
Lowes, Michelle A.; Bowcock, Anne M.; Krueger, James G.
PUB. DATE
February 2007
SOURCE
Nature;2/22/2007, Vol. 445 Issue 7130, p866
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.
ACCESSION #
24110160

 

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