Precision of Raman depolarization and optical attenuation measurements of sound tooth enamel

Sowa, Michael G.; Popescu, Dan P.; Werner, Jeffrey; Hewko, Mark; Ko, Alex C.-T.; Payette, Jeri; Dong, Cecilia C. S.; Cleghorn, Blaine; Lin-P'ing Choo-Smith
March 2007
Analytical & Bioanalytical Chemistry;Mar2007, Vol. 387 Issue 5, p1613
Academic Journal
The demineralization of enamel that is associated with early caries formation affects the optical properties of the enamel. Polarized Raman spectroscopy and optical coherence tomography have been used to detect these changes and potentially offer a means to detect and monitor early caries development. The total optical attenuation coefficient as measured by optical coherence tomography and the polarization anisotropy of the Raman peak arising from the symmetric ν1 vibration of $${\text{PO}}^{{{\text{3 - }}}}_{{\text{4}}} $$ at approximately 959 cm−1 have been demonstrated as being sensitive markers of early caries. This ex vivo study on extracted human teeth demonstrates that these measurements can be made with reasonable precision with concomitantly good repeatability and reproducibility in sound enamel. Such reliability is crucial for these techniques to have a practical clinical value.


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