Transmission of Drug-Resistant Tuberculosis among Treated Patients in Shanghai, China

Xia Li; Ying Zhang; Xin Shen; Guomiao Shen; Xiaohong Gui; Bin Sun; Jian Mei; DeRiemer, Kathryn; Small, Peter M.; Qian Gao
March 2007
Journal of Infectious Diseases;3/15/2007, Vol. 195 Issue 6, p864
Academic Journal
We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.


Related Articles

  • Human Tuberculosis due to Mycobacterium bovis in the United States, 1995-2005. Hlavsa, Michele C.; Moonan, Patrick K.; Cowan, Lauren S.; Navin, Thomas R.; Kammerer, J. Steve; Morlock, Glenn P.; Crawford, Jack T.; LoBue, Philip A. // Clinical Infectious Diseases;7/15/2008, Vol. 47 Issue 2, p168 

    Background. Understanding the epidemiology of human Mycobacterium bovis tuberculosis (TB) in the United States is imperative; this disease can be foodborne or airborne, and current US control strategies are focused on TB due to Mycobacterium tuberculosis and airborne transmission. The National...

  • Mycobacterial Interspersed Repetitive Unit typing in Mycobacterium tuberculosis isolates from Sichuan Province in China. Jian-hua Guo; Wen-liang Xiang; Geng Zhang; Tao Luo; Ning Xie; Zhi-rong Yang; Qun Sun // Indian Journal of Medical Research;Sep2011, Vol. 134 Issue 3, p362 

    Background & objectives: Emergence and spread of d rug resistant Mycobacterium tuberculosis is a serious threat to tuberculosis (TB) control programme. Therefore, the objective of this study was to genotype drug-resistant M. tuberculosis strains isolated from patients in Sichuan, China, using...

  • Risk factors for multidrug resistant tuberculosis in Europe: a systematic review. Faustinu, A.; Hall, A. J.; Perucci, C. A. // Thorax;Feb2006, Vol. 61 Issue 2, p158 

    Background: The resurgence of tuberculosis (TB) in western countries has been attributed to the HIV epidemic, immigration, and drug resistance. Multidrug resistant tuberculosis (MDR-TB) is caused by the transmission of multidrug resistant Mycobacterium tuberculosis strains in new cases, or by...

  • Transmission in the United States Virgin Islands and Florida of a Multidrug-Resistant Mycobacterium tuberculosis Strain Acquired in Puerto Rico. Reichler, Mary R.; Valway, Sarah E.; Onorato, Ida M. // Clinical Infectious Diseases;3/1/2000, Vol. 30 Issue 3, p617 

    Discusses the transmission in the United States Virgin Islands and Florida of a multidrug-resistant Mycobacterium tuberculosis strain acquired in Puerto Rico. Potential sources of M. tuberculosis transmission to the patient; Extent of transmission of the strain; Importance of maintaining an...

  • Modification of proportion sensitivity testing method for ethionamide. Lakshmi, Rajagopalan; Ramachandran, Ranjani; Devika, K.; Radhika, G.; Syam Sundar, A.; Rahman, Fathima; Selvakumar, N.; Kumar, Vanaja // World Journal of Microbiology & Biotechnology;Jun2013, Vol. 29 Issue 6, p1117 

    Standardized methodology for drug susceptibility testing of second line drugs is vital for treatment of multi/extensively drug resistant tuberculosis. Discrepancy between laboratory methods and clinical interpretation is well established for bacteriostatic drugs such as ethionamide. Optimization...

  • Rate and Amplification of Drug Resistance among Previously-Treated Patients with Tuberculosis in Kampala, Uganda. Temple, Beth; Ayakaka, Irene; Ogwang, Sam; Nabanjja, Helen; Kayes, Susan; Nakubulwa, Susan; Worodria, William; Levin, Jonathan; Joloba, Moses; Okwera, Alphonse; Eisenach, Kathleen D.; McNerney, Ruth; Elliott, Alison M.; Smith, Peter G.; Mugerwa, Roy D.; Ellner, Jerrold J.; Jones-López, Edward C. // Clinical Infectious Diseases;11/1/2008, Vol. 47 Issue 9, p1126 

    Background. Drug-resistant Mycobacterium tuberculosis has emerged as a global threat. In resource-constrained settings, patients with a history of tuberculosis (TB) treatment may have drug-resistant disease and may experience poor outcomes. There is a need to measure the extent of and risk...

  • Impact of Bacterial Genetics on the Transmission of Isoniazid-Resistant Mycobacterium tuberculosis. Gagneux, Sebastien; Burgos, Marcos V.; DeRiemer, Kathryn; Enciso, Antonio; Muñoz, Samira; Hopewell, Phillip C.; Small, Peter M.; Pym, Alexander S.; Ramakrishnan, Lalita // PLoS Pathogens;Jun2006, Vol. 2 Issue 6, pe61 

    Understanding the ecology of drug-resistant pathogens is essential for devising rational programs to preserve the effective lifespan of antimicrobial agents and to abrogate epidemics of drug-resistant organisms. Mathematical models predict that strain fitness is an important determinant of...

  • Increasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa. Shah, N. Sarita; Richardson, Jessica; Moodley, Prashini; Moodley, Salona; Babaria, Palav; Ramtahal, Melissa; Heysell, Scott K.; Xuan Li; Moll, Anthony P.; Friedland, Gerald; Sturm, A. Willem; Gandhi, Neel R. // Emerging Infectious Diseases;Mar2011, Vol. 17 Issue 3, p510 

    We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa. Of 19 patients with extensively drug-resistant TB identified during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs...

  • Simple low-cost test for drug-resistant tuberculosis. Toma, Tudor // Bulletin of the World Health Organization;2000, Vol. 78 Issue 11, p1370 

    Reports on the development of a test kit used to identify Mycobacterium tuberculosis isolates resistant to rifampicin. Use for large numbers of tubercular strains and susceptibility to streptomycin; Virus which infects and multiplies within live mycobacteria; Technology of rapid phage-based...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics