TITLE

Pravastatin and cancer: an unproven association

AUTHOR(S)
Brophy, James M.
PUB. DATE
February 2007
SOURCE
CMAJ: Canadian Medical Association Journal;2/27/2007, Vol. 176 Issue 5, p646
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article reports on the overall association between pravastatin use and cancer. The study uses meta-regression analysis which involves a linear regression model developed from the individual trials. Statins produce large cardiovascular benefits, specifically in the secondary prevention of cardiovascular disease.
ACCESSION #
24091850

 

Related Articles

  • Statin therapy for cardiovascular disease. Thomas, Susan // Practice Nurse;11/23/2007, Vol. 34 Issue 9, p34 

    The article considers statin therapy for cardiovascular disease. Research has shown that statins reduce the risk of cardiovascular events in primary and secondary prevention. The five statins currently licensed for use in Great Britain are simvastatin, atorvastatin, fluvastatin, pravastatin, and...

  • Registrar: Pros and cons of the polypill. Newson, Louise // GP: General Practitioner;6/17/2005, p61 

    The article informs that statins, aspirin and beta-blockers used in combination are known to improve survival in high-risk patients with cardiovascular disease. The combination would prevent heart disease and stroke by reducing four different risk factors--blood pressure, lipid concentration,...

  • Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage. Lakha, Fatim; Theodoratou, Evropi; Farrington, Susan M.; Tenesa, Albert; Cetnarskyj, Roseanne; Din, Farhat V.N.; Porteous, Mary E.; Dunlop, Malcolm G.; Campbell, Harry // BMC Cancer;2012, Vol. 12 Issue 1, p487 

    Background: In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival....

  • Exposure to statins and risk of common cancers: a series of nested case-control studies.  // BMC Cancer;2011, Vol. 11 Issue 1, p409 

    The article presents a large population-based case-control study of patients with primary cancers diagnosed between 1998 and 2008 to analyze the association between statin use and risk of several site-specific cancers. It is given that the impact of statin is examined by estimating conditional...

  • Very low LDL targets lead to other risks.  // GP: General Practitioner;6/9/2006, p6 

    The article reports that the aggressive cholesterol targets set for the primary prevention of cardiovascular disease could see most adults taking statins. The U.S. researchers said that U.S. guidelines to lower low-density lipoprotein cholesterol to below 1.81mmol/l in high-risk individuals...

  • The Association Between Statins and Cancer Incidence in a Veterans Population. Farwell, Wildon R.; Scranton, Richard E.; Lawler, Elizabeth V.; Lew, Robert A.; Brophy, Mary T.; Fiore, Louis D.; Gaziano, J. Michael // JNCI: Journal of the National Cancer Institute;1/16/2008, Vol. 100 Issue 2, p134 

    Background: Meta-analyses of trials of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors or statins for cardiovascular disease prevention have failed to show any statistically significant benefit of statins for cancer prevention. However, these trials included relatively young participants,...

  • The Effect of Low-Dose Pravastatin in Metabolic Syndrome for Primary Prevention of Cardiovascular Disease in Japan: A Post hoc Analysis of the MEGA Study. Matsushima, Teruhiko; Nakaya, Noriaki; Mizuno, Kyoichi; Ohashi, Yasuo; Teramoto, Tamio; Yokoyama, Shinji; Ichikawa, Shuichi; Ishikura, Norio; Kamiyama, Kimihide; Nakamura, Haruo // Journal of Cardiovascular Pharmacology & Therapeutics;Jun2012, Vol. 17 Issue 2, p153 

    The Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study demonstrated the beneficial effect of low-dose pravastatin treatment (10-20 mg/d) on cardiovascular disease (CVD) in Japanese patients with mild-to-moderate hypercholesterolemia. However, it is...

  • Cardiovascular disease: Intensive care. Fratntz, Simon // Nature Reviews Drug Discovery;Apr2004, Vol. 3 Issue 4, p297 

    Statin studies agree that the more intensive low density lipoprotein-cholesterol-lowering effects of atorvastatin provide superior surrogate and clinical benefits to the moderate effects of pravastatin. The observed clinical effects show that more patients should be treated with...

  • Statins equivalent for CVD prevention.  // Journal of Family Practice;May2006, Vol. 55 Issue 5, p381 

    The article presents information on the research conducted on the benefits of stains to prevent a cardiovascular disease (CVD) with various statins pravastatin or Pravachol, simvastatin or Zocor and atorvastatin or Liptor. 1000 participants were included which evaluated for one year and only...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics