Necessary cautions when considering digoxin in heart failure

Heckman, George A.; McKelvie, Robert S.
February 2007
CMAJ: Canadian Medical Association Journal;2/27/2007, Vol. 176 Issue 5, p644
Academic Journal
This article focuses on a study to assess the impact of digoxin on survival in heart failure. The study assessed the effect of digoxin on mortality and hospital admission in 6,800 patients with heart failure, a left-ventricular ejection fraction less than 45 percent. It also discusses the benefits of digitalis in cases of dropsy and its clinical efficacy in heart failure.


Related Articles

  • The End of the Digoxin Era? Manolis, Antonis S. // Hospital Chronicles;2015, Vol. 10 Issue 4, p197 

    Digoxin is one of the oldest of cardiovascular drugs which is still frequently used, both in patients with atrial fibrillation (AF) and patients with heart failure with or without AF. The use of digoxin preceded the era of evidence based medicine. However, over the recent past, there has been...

  • Digitalis: a dangerous drug in atrial fibrillation? An analysis of the SPORTIF Ill and V data. Gjesdal, K.; Feyzi, J.; Olsson, S. B. // Heart;Feb2008, Vol. 94 Issue 2, p191 

    Objective: In heart failure, digitalis increases exercise capacity and reduces morbidity, but has no effect on survival. This raises the suspicion that the inotropic benefits of digitalis may be counteracted by serious adverse effects. Patients with atrial fibrillation (AF) were studied to...

  • Phase-Invariant Signature Algorithm. Prasad, Kailash; Gupta, Madan M. // Angiology;Nov1979, Vol. 30 Issue 11, p721 

    Focuses on a noninvasive technique for early detection and quantification of Ouabain-induced cardiac disorders. Usage of the treatment; Methodology; Data acquisition and processing.

  • digoxin.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p654 

    A definition of the term "digoxin" which refers to digitalis glycoside that is frequently prescribed is presented.

  • Effect of quinidine on plasma concentrations of digoxin. Ejvinsson, Gunnar // British Medical Journal;2/4/1978, Vol. 1 Issue 6108, p279 

    Examines the effect of quinidine on plasma concentration of digoxin. Determination of quinidine concentration; Symptoms of digitalis intoxication; Use of radioimmunoassay in determining digoxin concentration.

  • Alternatives to the digitalis glycosides for heart failure. Johnston, G.D. // British Medical Journal (Clinical Research Edition);3/16/1985, Vol. 290 Issue 6471, p803 

    Examines the importance of digitalis glycosides for heart failure. Increase of cardiac output; Consideration of the forms of dopamine; Improvement of ventricular functions.

  • How digitalis is used and abused.  // Modern Medicine;Apr97, Vol. 65 Issue 4, p35 

    Focuses on the use and abuse of digitalis for chronic heart failure treatment. Inotropic effect of low-dose digoxin; Deterioration of patients with chronic heart failure after the withdrawal of digoxin.

  • Routine clinical variables predicted mortality in patients with heart failure and systolic dysfunction. Kent, David M. // Evidence Based Medicine;Sep/Oct2004, Vol. 9 Issue 5, p154 

    The article provides an answer to a question on the significance of clinical variables in the prediction of mortality rates of patients with systolic dysfunction and heart failure.

  • Age- and Gender-Specific Incidence of Hospitalisation for Digoxin Intoxication. Aarnoudse, Adrianus L. H. J.; Dieleman, Jeanne P.; Stricker, Bruno H.Ch. // Drug Safety;2007, Vol. 30 Issue 5, p431 

    Background: The safety of digoxin (digitalis) therapy has greatly improved over the past three decades, but recent incidence rates for digoxin intoxication-related hospitalisation are not available. Recent literature suggests that women are at higher risk of digoxin toxicity. Objective: To...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics