TITLE

Prevalence of Silent Celiac Disease in Patients with Dyspepsia

AUTHOR(S)
Ersan Özaslan; Sertuğ Akkorlu; Erdal Eskioğlu; Burçak Kayhan
PUB. DATE
March 2007
SOURCE
Digestive Diseases & Sciences;Mar2007, Vol. 52 Issue 3, p692
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract??Celiac disease (CD) has become more common than in the past, although it frequently remains undetected for long periods of time. One reason for this is failure by health care professionals to recognize the variable clinical manifestations of CD and to perform the appropriate tests to make the diagnosis. Although dyspepsia may be part of a clinical spectrum in CD patients, there are scarce data about its prevalence in silent CD. We aimed to determine the prevalence of CD in otherwise healthy dyspeptic patients by means of serologic screening followed by endoscopic biopsies if appropriate. Anti-endomysium antibody assay was positive in 3 of 196 patients. All 3 were female, ages ranged from 19?52 years (mean ? SD age, 36?16 years). Duodenal biopsies were compatible with CD in all, whereas abnormal endoscopic findings were noted in 2. Therefore, a 1.5% prevalence of CD was observed in this study group. The odds ratio for CD was 2.57 (95% confidence interval) in comparison with the general population. CD should be kept in mind as a cause of dyspepsia during clinical activities. The association between these 2 conditions is, at most, weak, but a gluten-free diet may still bring symptomatic relief for dyspeptic symptoms in CD. During endoscopic examination for dyspepsia, if indicated, endoscopists should carefully inspect the duodenum for CD findings. Although routine serologic screening can not be recommended, it may be appropriate for the patients with refractory dyspepsia, especially females.
ACCESSION #
24079634

 

Related Articles

  • Commentary: Reaching a milestone in diagnosing coeliac disease. Graber, Mark L.; Kumar, Atul // BMJ: British Medical Journal (International Edition);4/7/2007, Vol. 334 Issue 7596, p732 

    The article presents the authors' reactions to medical research which reported on a medical decision rule that achieved 100% sensitivity in disease detection with celiac disease. Arguments are presented which suggest that the decision rule used in the research could prove helpful in diagnosing...

  • Coeliac disease increase.  // GP: General Practitioner;5/17/2004, p6 

    The article focuses on the research works that are going on with regard to the coeliac diseases. Although research has found that coeliac disease is more common than previously thought, it is still under-diagnosed, says Dr Sohail Butt, associate member of Coeliac Great Britain's medical advisory...

  • Anticorpii antitransglutaminază tisulară. SAMAŞCA, GABRIEL; PÎRVAN, ALEXANDRU; FARCĂU, DORIN; DEJICA, DORU // Romanian Journal of Medical Practice;2010, Vol. 5 Issue 2, p88 

    Discovery of tissue transglutaminase marked a new era in the diagnosis of celiac disease. With all the new challenges, immunoenzymatic assay for determining tissue transglutaminase remained the most effective in celiac disease screening.

  • Screening for Celiac Disease: A Prospective Study on the Value of Noninvasive Tests. Vogelsang, Harald; Genser, Dieter; Wyatt, John; Lochs, Herbert; Ferenci, Peter; Granditsch, Gerhard; Penner, Edward // American Journal of Gastroenterology;Mar1995, Vol. 90 Issue 3, p394 

    Objective: Celiac disease is frequently diagnosed in patients with nonspecific abdominal symptoms. Therefore, highly sensitive, specific, and simple noninvasive screening tests are needed. Methods: This study compared the usefulness of IgG- and IgA-antigliadin antibodies, IgA-endomysial...

  • Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency: an alternative pathway. Harrison, Elizabeth; Ka-Kit Li; Petchey, Michael; Nwokolo, Chuka; Loft, Duncan; Arasaradnam, Ramesh P. // Postgraduate Medical Journal;Jan2013, Vol. 89 Issue 1047, p4 

    Objective To determine the ability of selective antibody testing to screen for coeliac disease in the presence of IgA deficiency and to define the sensitivity of a pathway using this method. Method All IgA and IgG anti-tTG tests performed at our centre between January 2008 and December 2009,...

  • Coeliac disease: an update for pathologists. B C Dickson // Journal of Clinical Pathology;Oct2006, Vol. 59 Issue 10, p1008 

    Coeliac disease is the manifestation of an immune hypersensitivity reaction towards gluten and related proteins, in genetically predisposed people. Although the precise pathogenesis of this condition remains to be fully elucidated, it is probably multifactorial in origin. The diagnosis of...

  • Comparison of D-Xylose Hydrogen Breath Test With Urinary D-Xylose Test in Indian Children With Celiac Disease. S. Rana; B. Thapa; R. Pal // Digestive Diseases & Sciences;Mar2007, Vol. 52 Issue 3, p681 

    Abstract??D-xylose hydrogen breath test (H2BT) may be better parameter in screening for intestinal malabsorption in patients with celiac disease. This study sought to compare D-xylose H2BT with urinary D-xylose tests in screening for intestinal malabsorption in patients with celiac disease. A...

  • Celiac Disease Goes Underdiagnosed.  // Tufts University Health & Nutrition Letter;Oct2004, Vol. 22 Issue 8, p8 

    Presents information on celiac disease. Symptoms of the disease; Diagnosis and management of celiac disease; Suggestions for people diagnosed with the disease.

  • Compact Guidelines: Commentary - Your weekly review of key GP guidance from MIMS. Gnanapragasam, Vasa // GP: General Practitioner;6/1/2005, p63 

    The article focuses on the coeliac disease. Most patients with coeliac disease are discharged from the gastroenterology clinic once the diagnosis is confirmed, and then the general practitioner is responsible for continuing care. An annual medication review is a good time to follow up on these...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics