TITLE

High Proportions of Proinflammatory Bacteria on the Colonic Mucosa in a Young Patient with Ulcerative Colitis as Revealed by Cloning and Sequencing of 16S rRNA Genes

AUTHOR(S)
Mei Wang; Göran Molin; Siv Ahrné; Diya Adawi; Bengt Jeppsson
PUB. DATE
March 2007
SOURCE
Digestive Diseases & Sciences;Mar2007, Vol. 52 Issue 3, p620
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract??The pathogenesis of ulcerative colitis (UC) remains unknown. It is thought to be due to an abnormal and uncontrolled immune response to normally occurring constituents of the intestine. Microbial agents appear to be involved in the pathogenesis and intestinal bacteria seem to be an important factor in the development and chronicity. The aim of this study was to investigate the colonic microbiota of a patient with UC. The colonic tissues were taken during surgery from a 12-year-old girl suffering from UC. The microbiota on the colonic samples was studied by cloning and sequencing of amplified 16S rRNA genes. Compared with healthy subjects, alteration of the dominant bacterial group was observed in the UC patient. We found a high incidence ofEnterobacteriaceae,Bacteroides fragilis, and the single phylotype of theFaecalibacterium prausnitzii-like ?Butyrate-producing bacterium? L2-6. Furthermore, there was a substantial presence ofPseudomonas aeruginosain the present case of UC. The high proportion of adverse proinflammatory species is striking in the present case compared with more normal situations. Even if those bacteria are not the cause of the UC, they most probably enhance the symptoms of the disease.
ACCESSION #
24079631

 

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