l -Glutamine, A Liquid-Stable Source of Glutamine, Partially Prevents Changes in Body Weight and on Intestinal Immunity Induced by Protein Energy Malnutrition in Pigs. Get access to over 12 million other articles!" />

N-Acetyl-l -Glutamine, A Liquid-Stable Source of Glutamine, Partially Prevents Changes in Body Weight and on Intestinal Immunity Induced by Protein Energy Malnutrition in Pigs

José López-Pedrosa; Manuel Manzano; Jeffrey Baxter; Ricardo Rueda
March 2007
Digestive Diseases & Sciences;Mar2007, Vol. 52 Issue 3, p650
Academic Journal
Abstract??The goal of this study was to evaluate the preventive effect of free glutamine versusN-acetyl-l-glutamine, a liquid-stable source of glutamine, on gut damage induced by protein energy malnutrition in pigs. Healthy pigs (n=6) were fed a liquid formula for 30 days. Three subgroups of malnourished pigs (n=6) received daily 20% of the food intake recorded in control group, supplemented with calcium caseinate, glutamine, orN-acetyl-l-glutamine. Body weight was recorded, and small intestinal samples were evaluated for biochemical and immunologic parameters. Suppression in body weight gain was significantly lower in pigs fed withN-acetyl-l-glutamine than in the rest of malnourished pigs. Total number of lymphocytes, CD21+B cells and CD4+T cells in ileal Peyer patches were not significantly different in malnourished pigs fed withN-acetyl-l-glutamine and in healthy pigs. In conclusion,N-acetyl-l-glutamine has a moderate protective effect, partially preventing changes induced by protein energy malnutrition.


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