TITLE

APOPTOSIS OF T CELLS AND THE CONTROL OF INFLAMMATORY BOWEL DISEASE: THERAPEUTIC IMPLICATIONS

AUTHOR(S)
Mudter, J.; Neurath, M. F.
PUB. DATE
February 2007
SOURCE
Gut;Feb2007, Vol. 56 Issue 2, p293
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are the result of an imbalanced mucosal T cell response. Despite the identification of a genetic susceptibility region in the NOD2/CARD15 (nucleotide-binding oligomerisation domain 2/caspase recruitment domain 15)gene, the aetiology is still unclear. Thus, the hunt for disease-initiating factors such as defects in the mucosal barrier or pathogenic microorganisms is ongoing. By contrast, the immunopathogenesis in IBDs is better understood. The identification of cytokines that are involved in T cell and monocyte signalling led to specific therapeutic concepts. Recent data have clearly shown that the most powerful therapeutic approaches inhibit T cell survival by inducing apoptosis. The efficacy of anti-tumour necrosis factor (TNF) strategies was proved to be at least partially due to its ability to induce apoptosis in T cells and monocytes. Furthermore, other powerful anticytokine strategies—namely, anti-interleukin (IL)12 and anti-IL6 antibodies, which are currently tested in clinical trials—also inhibit antiapoptotic pathways in T cells. Recently, the well-established immunosuppressive drug azathioprine was identified as blocking antiapoptotic pathways in T cells. Data from these studies underline the pivotal role of lymphocyte apoptosis in the regulation of mucosal immune balance.
ACCESSION #
24040276

 

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