Low Rate of Sex-Specific Result Reporting in Cardiovascular Trials

Blauwet, Lori A.; Hayes, Sharonne N.; McManus, David; Redberg, Rita F.; Walsh, Mary Norine
February 2007
Mayo Clinic Proceedings;Feb2007, Vol. 82 Issue 2, p166
Academic Journal
OBJECTIVE: To explore the extent to which sex-specific result (SSR) reporting appears In recently published cardiovascular studies. METHODS: All original adult cardiovascular clinical trials published in Annals of Internal Medicine, Archives of Internal Medicine, Journal of the American Medical Association, The New England Journal of Medicine, Journal of the American College of Cardiology, The American Journal of Cardiology, and Circulation from July 1 through December 31, 2004, were reviewed. Sex-specific result reporting was defined as presenting primary outcomes for women in a format to allow the data to be abstracted for use In a meta-analysis. RESULTS: Of the 645 studies reviewed, 17 were excluded because they were appropriately single-sex trials. Of the remaining 628 studies, only 153 (24%) provided SSRs. The percentage of studies reporting SSR5 was 37% (23/62) for general medical Journals and 23% (130/566) for cardiovascular Journals (P=.10). Among National Institutes of Health (NIH)-sponsored research, 31 (51%) of 61 trials analyzed outcomes by sex compared with 125 (22%) of 567 trials not sponsored by the NIH (P<.001). CONCLUSION: Only a few current cardiovascular trials provide sex-specific data. Sex differences remain poorly understood, and this deficiency limits our ability to optimize medical care for both sexes. The stipulation that SSRs be Investigated has led to significantly more SSR reporting In NIH-funded research. A parallel mandate by Journal editors that requires authors to provide sex-specific data and analysis may help to bridge this knowledge gap.


Related Articles

  • Airway foreign body. Verret, D. J.; Todd Adelson, Robert; McClay, John // ENT: Ear, Nose & Throat Journal;Sep2004, Vol. 83 Issue 9, p605 

    Presents a case of delayed diagnosis of a safety pin lodged in the trachea of an 8-month-old girl. Results of the initial examination; Method used to remove the foreign body; Reason behind the refusal of the patient to eat.

  • The modern scientific physician: 6. The useful property of a screening regimen. Miettinen, Olli S. // CMAJ: Canadian Medical Association Journal;10/30/2001, Vol. 165 Issue 9, p1219 

    Argues that a screening regimen is very useful to the modern scientific physician. How diagnostics and interventions are challenging to conceptualize; Definition of screening and other medical terminology.

  • New Test May Be an Easy,Inexpensive Way to Screen for Testicular Cancer. Hogle, William P. // Clinical Journal of Oncology Nursing;Jun2005, Vol. 9 Issue 3, p291 

    Provides information on a test developed by researchers in Denmark which detects early signs of testicular cancer. Significance of the test in the diagnosis and screening of testicular cancer.

  • Analysing the Output from Primary Screening. Nowlin, Dawn; Bingham, Patrick; Berridge, Andrew; Gribbon, Philip; Laflin, Philip; Sewing, Andreas // Combinatorial Chemistry & High Throughput Screening;Jun2006, Vol. 9 Issue 5, p331 

    From a perspective of process knowledge and enhancement, the analysis of the results of biological screening should not be limited to the outcome of specific projects, but additionally encompass a process centric view. Summarising outcomes across multiple projects is a powerful tool to gain a...

  • Experts call for improved reporting, better clinical trials.  // Endocrine Today;Nov2011, Vol. 9 Issue 11, p23 

    The article highlights the views of experts, such as Rury R. Holman, on the need for a systematic approach to assess clinical trials and improve reporting of clinical trial findings.

  • Clinical trial regulation in Argentina: overview and analysis of regulatory framework, use of existing tools, and researchers' perspectives to identify potential barriers. White, Lauren; Ortiz, Zulma; Cuervo, Luis G.; Reveiz, Ludovic // Pan American Journal of Public Health;Nov2011, Vol. 30 Issue 5, p445 

    Objective. To review and analyze the regulatory framework of clinical trial registration, use of existing tools (publicly accessible national/international registration databases), and users' perspectives to identify possible barriers to registration compliance by sponsors and researchers in...

  • Misleading Reporting of Research Results: a Widespread Problem. Gaby, Alan R. // Townsend Letter;Nov2010, Issue 328, p94 

    The author reflects on the results of a study which analyzed how frequently the treatment being investigated by researchers appeared to be more effective than the data actually indicated. He introduces the prevalence of spin reporting by researchers, which uses reporting strategies indicating...

  • Clinical trials registered in clinical trial registry of India: A survey. Yadav, Jaykaran Preeti; Chaudhari, Mayur; Saxena, Deepak; Kantharia, N. D. // Journal of Pharmacology & Pharmacotherapeutics;Oct2011, Vol. 2 Issue 4, p289 

    The article reports on a survey which aims to solve problems associated with the quality of reporting of clinical trials in India. It mentions that one of the important problems associated with clinical trial reporting is selective reporting wherein it is observed that some pharmaceutical...

  • Statement on Publishing Clinical Trials in Indian Biomedical Journals. Satyanarayana, K.; Sharma, Anju; Parikh, Purvish; Vijayan, V. K.; Sahu, D. K.; Nayak, Barun K.; Gulati, R. K.; Parikh, Mahendra N.; Singh, Prati Pal; Bavdekar, S. B.; Sreehari, U.; Sahni, Peush // Indian Journal of Medical Research;Feb2008, Vol. 127 Issue 2, p104 

    The article focuses on the registration of clinical trials conducted in India to the online registry Clinical Trial Registry India (CTRI). According to the author, registration of clinical trials will help improve the reliability of clinical data generated, minimize duplication of trials,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics