The effect of intensive lipid lowering on coronary atheroma and clinical outcome

Houslay, Emma S.; Sarma, Jaydeep; Uren, Neal G.
February 2007
Heart;Feb2007, Vol. 93 Issue 2, p149
Academic Journal
The association between raised plasma cholesterol and cardiovascular risk is well established, with consistent evidence associating LDL-cholesterol reduction with a reduction in primary and secondary cardiovascular events. It is believed that intensive lipid lowering may improve clinical outcomes further by acting to stabilise plaque and preventing plaque progression, ultimately reducing plaque vulnerability. However, it remains uncertain whether a continued clinical benefit occurs with intensive lipid lowering or if there is a threshold level below which no further benefit occurs.


Related Articles

  • THE ROLE OF DIET IN TREATMENT OF LIPID METABOLISM DISORDERS. Regula, Julita // Acta Scientiarum Polonorum. Technologia Alimentaria;2009, Vol. 8 Issue 3, p97 

    Apart from arterial hypertension the most frequent risk factor for cardiovascular diseases is connected with lipid metabolism disorders, which according to studies conducted to date in Poland affect over half of the adult population. Diet plays a significant role in the regulation of lipid...

  • Prospects for atherosclerosis regression through increase in high-density lipoprotein and other emerging therapeutic targets. Lee, Justin M. S.; Choudhury, Robin P. // Heart;May2007, Vol. 93 Issue 5, p559 

    In a process often seen as progressive and irreversible, deposition and retention of lipoproteins and the consequent inflammatory reaction result in the accumulation of atherosclerotic plaques from an early age. However, striking effects observed in experimental models support the concept that...

  • Relationship between cardiovascular risk factors and biomarkers with necrotic core and atheroma size: a serial intravascular ultrasound radiofrequency data analysis. García-García, Héctor; Klauss, Volker; Gonzalo, Nieves; Garg, Scot; Onuma, Yoshinobu; Hamm, Christian; Wijns, William; Shannon, Jennifer; Serruys, Patrick // International Journal of Cardiovascular Imaging;Apr2012, Vol. 28 Issue 4, p695 

    We explored the impact of patient demographics, anthropometric measurements, cardiovascular risk factors, and soluble biomarkers on necrotic core and atheroma size in patients with coronary disease. The IBIS-2 trial enrolled 330 patients. In the multivariate analysis, at baseline, creatinine had...

  • Cardiovascular Risk Factors in the Antiphospholipid Syndrome. da Silva, Felipe Freire; Abramino Levy, Roger; de Carvalho, Jozélio Freire // Journal of Immunology Research;2014, p1 

    A major cause of morbidity and mortality in the context of the antiphospholipid syndrome (APS) is the occurrence of thrombotic events. Besides the pathogenic roles of antiphospholipid antibodies (aPL), other risk factors and medical conditions, which are conditions for traditional risk of an...

  • HDL Size is More Accurate than HDL Cholesterol to Predict Carotid Subclinical Atherosclerosis in Individuals Classified as Low Cardiovascular Risk. Parra, Eliane Soler; Panzoldo, Natalia Baratella; Zago, Vanessa Helena de Souza; Scherrer, Daniel Zanetti; Alexandre, Fernanda; Bakkarat, Jamal; Nunes, Valeria Sutti; Nakandakare, Edna Regina; Quintão, Eder Carlos Rocha; Nadruz-Jr, Wilson; de Faria, Eliana Cotta; Sposito, Andrei C. // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Background: Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential...

  • Algo más que inflamación vascular. García-Frade Ruíz, Luis Fernando; Arredondo Sandoval, José de Jesús // Medicina Interna de Mexico;nov/dic2010, Vol. 26 Issue 6, p597 

    No abstract available.

  • Vascular endothelium in atherosclerosis. Sima, Anca V.; Stancu, Camelia S.; Simionescu, Maya // Cell & Tissue Research;Dec2008, Vol. 335 Issue 1, p191 

    Their strategic location between blood and tissue and their constitutive properties allow endothelial cells (EC) to monitor the transport of plasma molecules, by employing bidirectional receptor-mediated and receptor-independent transcytosis and endocytosis, and to regulate vascular tone,...

  • HIGH CARDIOVASCULAR RISK IN PATIENTS WITH PSORIASIS. Arora, Megha Kataria; Seth, Shashi; Seth, Mamta // International Journal of Pharma & Bio Sciences;Jan-Mar2011, Vol. 2 Issue 1, pB155 

    Objective Dyslipidemia is one of the important risk factor for cardiovascular disease so present study was planned to evaluate risk of cardiovascular disease in patients with psoriasis. Design and Methods It was a hospital based case control study performed in the 85 patients of psoriasis with...

  • Acute Passivation of Vulnerable Plaques with Wild-Type Apolipoprotein A-I in ApoE-Deficient Mice. Laurberg, Jacob M.; Graversen, Jonas H.; Moestrup, Soren K.; Holmberg, Heidi L.; Falk, Erling // Vascular Disease Prevention;Oct2007, Vol. 4 Issue 4, p314 

    Objective: The apolipoprotein A-I (apoA-I) variant apoA-IMilano has rapid passivating effects on atherosclerotic plaques. In this study we tested if human wild-type apoA-I can likewise rapidly mobilize cholesterol and reduce inflammation and lipid contents of atherosclerotic plaques. Methods and...


Read the Article


Sign out of this library

Other Topics