Prophylactic and therapeutic approaches to acute lung injury, targeting alveolar epithelial type II cells

Mikawa, Katsuya; Nishina, Kahoru; Misumi, Takuyo; Ando, Toshihiro; Obara, Hidefumi
February 2007
Journal of Anesthesia;2007, Vol. 21 Issue 1, p120
Academic Journal
The article discusses the prophylactic and therapeutic approaches to acute lung injury (ALI) which targets alveolar epithelial type II cells (AEC-II). During the progress of ALI, the apoptosis of AEC-II contributes to the destruction alveolar epithelial architecture. AEC-II was tested to minimize growth of fibroblasts which usually is the main cause of death in the late phase of ALI. It also has the ability to produce inflammatory mediators during the manifestation and progression of ALI.


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