TITLE

Removal of pharmaceutical residues in a pilot wastewater treatment plant

AUTHOR(S)
Kosjek, Tina; Heath, Ester; Kompare, Boris
PUB. DATE
February 2007
SOURCE
Analytical & Bioanalytical Chemistry;Feb2007, Vol. 387 Issue 4, p1379
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Concern is growing over the contamination of the environment with pharmaceutical residues, among which non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most abundant groups. Their widespread appearance in the aquatic environment is because of their high consumption and their incomplete removal during wastewater treatment. Because effective operation of wastewater-treatment plants is important for minimising the release of xenobiotic compounds, for example pharmaceutical products, into the aquatic environment, our study focuses on removal of commonly used NSAIDs (ibuprofen, naproxen, ketoprofen, diclofenac) and clofibric acid in a specially designed small-scale pilot wastewater treatment plant (PWWTP). This study shows that, except for diclofenac, steady-rate removal of NSAIDs over a two-year monitoring period has been achieved. Elimination of the compounds in the PWWTP was ≥87% for ibuprofen, naproxen and ketoprofen but only 49–59% for diclofenac. We also studied clofibric acid. Results after one month of operation revealed 30% elimination with no sign of adaptation by the biomass. Also described are degradation products of diclofenac, which we were able to identify because of the similarity of their mass spectra with those in the NIST library and by comparing the retention times of different compounds. Although the structures of these compounds were confirmed with a high probability (99%), we still need to compare the fragmentation of authentic compounds with degradation products formed under our experimental conditions. Degradation products of ibuprofen, naproxen, ketoprofen, and clofibric acid were found but these must be identified by use of high-resolution mass spectrometry and analysis of authentic compounds.
ACCESSION #
23905317

 

Related Articles

  • Determination of NSAIDs in river sediment samples. Antonić, Jan; Heath, Ester // Analytical & Bioanalytical Chemistry;Feb2007, Vol. 387 Issue 4, p1337 

    Consumption of non-steroidal anti-inflammatory drugs (NSAIDs) is increasing and with it the danger of environmental pollution by pharmaceutical residues. Publications regarding NSAIDs in the environment not only show that they are toxic to many animal species, but also highlight the need for...

  • Ultrasonic aiding of selected pharmaceuticals removal from wastewater. Próba, Marta; Wolny, Lidia; Zawieja, Iwona // Desalination & Water Treatment;May2014, Vol. 52 Issue 19-21, p3832 

    In the paper, the problem of water pollution risks with pharmaceuticals was discussed. The results of the investigation from different countries are shown. Polish results are presented as well. Particular emphasis was put on water pollution with non-steroidal anti-inflammatory and psychoactive...

  • Supramolecular Chiro-Biomedical Assays and Enantioselective HPLC Analyses for Evaluation of Profens as Non-Steroidal Anti-Inflammatory Drugs, Potential Anticancer Agents and Common Xenobiotics. Ali, Imran; Hussain, Iqbal; Saleem, Kishwar; Aboul-Enein, Hassan Y.; Bazylak, Grzegorz // Current Drug Discovery Technologies;Jun2008, Vol. 5 Issue 2, p105 

    The permanent world-wide increase in therapeutic administration of racemic profens as easy available non-prescribed analgesic drugs and a common first-choice anti-inflammatory agents was recently linked with renewed interest in their beneficial use, also as enantiopure formulations, to treat...

  • BOLD-MRI for the assessment of renal oxygenation in humans: Acute effect of nephrotoxic xenobiotics. Hofmann, L.; Simon-Zoula, S.; Nowak, A.; Giger, A.; Vock, P.; Boesch, C.; Frey, F. J.; Vogt, B. // Kidney International;Jul2006, Vol. 70 Issue 1, p144 

    Hypoxia of renal medulla is a key factor implicated in the development of drug-induced renal failure. Drugs are known to influence renal hemodynamics and, subsequently, affect renal tissue oxygenation. Changes in renal oxygenation can be assessed non-invasively in humans using blood oxygenation...

  • Update on nandrolone and norsteroids: how endogenous or xenobiotic are these substances? Bricout, V.; Wright, F. // European Journal of Applied Physiology;Jun2004, Vol. 92 Issue 1/2, p1 

    Norsteroids are xenobiotics with androgenic and anabolic properties known since as far back as the 1930s. In doping controls, the use of the banned xenobiotic norsteroids is detected in the competitor’s urines by the measurement of norandrosterone (19-NA) and noretiocholanolone (19-NE),...

  • Metals and Nonsteroidal Anti-inflammatory Pharmaceuticals Drugs Present in Water from Madín Reservoir (Mexico) Induce Oxidative Stress in Gill, Blood, and Muscle of Common Carp ( Cyprinus carpio). González-González, Edgar; Gómez-Oliván, Leobardo; Galar-Martínez, Marcela; Vieyra-Reyes, Patricia; Islas-Flores, Hariz; García-Medina, Sandra; Jiménez-Vargas, Juan; Razo-Estrada, Celene; Pérez-Pastén, Ricardo // Archives of Environmental Contamination & Toxicology;Aug2014, Vol. 67 Issue 2, p281 

    Many toxic xenobiotics that enter the aquatic environment exert their effects through redox cycling. Oxidative stress, which incorporates both oxidative damage and antioxidant defenses, is a common effect induced in organisms exposed to xenobiotics in their environment. The results of the...

  • Endocrine disrupters in the aquatic environment: the Austrian approach -- ARCEM. Bursch, W.; Fuerhacker, M.; Gemeiner, M.; Grillitsch, B.; Jungbauer, A.; Kreuzinger, N.; Moestl, E.; Scharf, S.; Schmid, E.; Skutan, S.; Walter, I. // Water Science & Technology;2004, Vol. 50 Issue 5, p293 

    A consortium of Austrian scientists (ARCEM) carried out a multidisciplinary environmental study on Austrian surface and ground waters including chemical monitoring, bioindication, risk assessment and risk management for selected endocrine disrupters: 17β-estradiol, estriol, estrone,...

  • Advanced enzymatic elimination of phenolic contaminants in wastewater: a nano approach at field scale. Gasser, Christoph; Yu, Liang; Svojitka, Jan; Wintgens, Thomas; Ammann, Erik; Shahgaldian, Patrick; Corvini, Philippe; Hommes, Gregor // Applied Microbiology & Biotechnology;Apr2014, Vol. 98 Issue 7, p3305 

    The removal of recalcitrant chemicals in wastewater treatment systems is an increasingly relevant issue in industrialized countries. The elimination of persistent xenobiotics such as endocrine-disrupting chemicals (EDCs) emitted by municipal and industrial sewage treatment plants remains an...

  • The effects of subchronic exposure to ketoprofen on early developmental stages of common carp. Prášková, Eva; Štěpánová, Stanislava; Chromcová, Lucie; Plhalová, Lucie; Voslářová, Eva; Pištěková, Vladimíra; Prokeš, Miroslav; Svobodová, Zdeňka // Acta Veterinaria Brno;2013, Vol. 82 Issue 3, p343 

    Ketoprofen residues have been found in surface water where they present a potential risk to nontarget aquatic species. The aim of this study was to assess the impact of ketoprofen in surface waters on fish under experimental conditions. Subchronic toxic effects on 300 embryos and larvae of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics