TITLE

Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout ( Oncorhynchus mykiss) and common carp ( Cyprinus carpio)

AUTHOR(S)
Triebskorn, R.; Casper, H.; Scheil, V.; Schwaiger, J.
PUB. DATE
February 2007
SOURCE
Analytical & Bioanalytical Chemistry;Feb2007, Vol. 387 Issue 4, p1405
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In order to assess potential effects of human pharmaceuticals in aquatic wildlife, laboratory experiments were conducted with carbamazepine, clofibric acid, metoprolol, and diclofenac using fish as test organisms. For each substance, at least one environmentally relevant concentration was tested. In liver, kidney, and gills of trout and carp exposed to carbamazepine, clofibric acid, and metoprolol, ultrastructural effects were qualitatively described and semi-quantitatively assessed. The obtained assessment values were compared with previously published data for diclofenac-induced effects in rainbow trout tissues. Quantitative analyses of protein accumulated in kidneys of diclofenac-exposed trout corroborated previously published data which indicated that diclofenac induced a severe glomerulonephritis resulting in a hyaline droplet degeneration of proximal kidney tubules. The investigations provided information on the general health status of the pharmaceutical-exposed fish, and allowed a differential diagnosis of harmful effects caused by these human pharmaceuticals in non-target species. For the different cytological effects observed, lowest observed effect concentration (LOECs) for at least three of the test substances (diclofenac, carbamazepine, metoprolol) were in the range of environmentally relevant concentrations (1 μg/L).
ACCESSION #
23905310

 

Related Articles

  • Recently developed GC/MS and LC/MS methods for determining NSAIDs in water samples. Farré, M.; Petrovic, M.; Barceló, D. // Analytical & Bioanalytical Chemistry;Feb2007, Vol. 387 Issue 4, p1203 

    Pharmaceuticals have become major targets in environmental chemistry due to their presence in aquatic environments (following incomplete removal in wastewater treatment or point-source contaminations), threat to drinking water sources and concern about their possible effects to wildlife and...

  • 'OH SAY, CAN YOU SEE...' WHAT WE'VE DONE TO THE SEA? Binney, Gard E. // Ecologist;Oct2001, Vol. 31 Issue 8, p61 

    Discusses the problems of ocean pollution and the aquatic environment as of October 2001. Description of the book `The Sea Around Us,' by Rachel Carson; Findings of the report `Vital Signs 2001,' by the Worldwatch Institute; Role of the United States National Oceanic and Atmospheric Administration.

  • An Overview of Substances Present in Canadian Aquatic Environments Associated with Endocrine Disruption. Hewitt, Mark; Servos, Mark // Water Quality Research Journal of Canada;2001, Vol. 36 Issue 2, p191 

    Numerous environmental contaminants have been associated with the ability to affect the endocrine status of animals and with the potential to elicit effects on individuals or populations in Canadian aquatic environments. Potential endocrine disrupting substances (EDS) consist of almost every...

  • Household Disposal of Pharmaceuticals as a Pathway for Aquatic Contamination in the United Kingdom. Bound, Jonathan P.; Voulvoulis, Nikolaos // Environmental Health Perspectives;Dec2005, Vol. 113 Issue 12, p1705 

    Pharmaceuticals are produced and used in increasingly large volumes every year. With this growth comes concern about the fate and effects of these compounds in the environment. The discovery of pharmaceuticals in the aquatic environment has stimulated research in the last decade. A wide range...

  • Surface Water Concentrations and Loading Budgets of Pharmaceuticals and Other Domestic-Use Chemicals in an Urban Watershed (Washington, DC, USA). Shala, Lirije; Foster, Gregory D. // Archives of Environmental Contamination & Toxicology;Apr2010, Vol. 58 Issue 3, p551 

    Pharmaceuticals and domestic-use chemicals (PDCs) are classes of emerging chemical contaminants thought to enter the aquatic environment primarily through wastewater treatment plant (WTP) discharges. The intent of this study was to quantify loadings of PDCs in an urban watershed. The watershed...

  • Persistent Organochlorine Pollutants in the Aquatic Ecosystem of Lake Manzala, Egypt. Abbassy, M. S.; Ibrahim, H. Z.; Abdel-Kader, H. M. // Bulletin of Environmental Contamination & Toxicology;Jun2003, Vol. 70 Issue 6, p1158 

    The article reports on persistent organochlorine pollutants in the aquatic ecosystem of lake Manzala, Egypt. Widespread contamination and toxic effects of Persistent Organic Pollutants have become a serious environmental problem. The present study aims at determining the levels of some...

  • Prescribing Update. Lobuono, Charlotte // Patient Care;5/15/2001, Vol. 35 Issue 9, p15 

    Presents several prescription drugs, indications and usage. Esomeprazole magnesium; Galantamine; Metoprolol ER.

  • Reproductive Toxins and Alligator Abnormalities at Lake Apopka, Florida.  // Environmental Health Perspectives;Oct1997, Vol. 105 Issue 10, p1 

    Presents information about the reproductive toxins and alligator abnormalities at Lake Apopka, Florida. Impact of chemical pollutants on the reproduction of alligators at the lake; Hypothesis pertaining to the concentration of chemicals in alligator's eggs.

  • Monitoring priority/priority dangerous substances in the SomeÅŸ-Tisa River Basin. Results and interpretation. Popa, Giana; Coşier, Viorica // Aquaculture, Aquarium, Conservation & Legislation - Internationa;Oct2009, Vol. 2 Issue 4, p339 

    Ensuring the quality management of the water source in the hydrographic basin SomeÅŸ-Tisa, in the acception of the Water Framework Directive 2000/60/EC, to reach to the good ecological status, involves the establishment of integrated monitoring and of some action plans for those sources that...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics