TITLE

Voltammetric behavior of some fluorinated quinolone antibacterial agents and their differential pulse voltammetric determination in drug formulations and urine samples using a �-cyclodextrin-modified carbon-paste electrode

AUTHOR(S)
Reddy, T. Madhusudana; Balaji, K.; Reddy, S. Jayarama
PUB. DATE
February 2007
SOURCE
Journal of Analytical Chemistry;Feb2007, Vol. 62 Issue 2, p168
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A voltammetric determination of ofloxacin (OF), norfloxacin (NF), gatifloxacin (GF), and lomefloxacin (LF) at a �-cyclodextrin-modified carbon-paste electrode (CDMCPE) is described. A large increase in the peak currents was observed in cyclic voltammetry (CV) and differential pulse voltammetry (DPV) of OF, NF, GF, and LF at CDMCPE compared with a bare carbon-paste electrode (CPE). These increases in the peak currents were attributed to the complex formation of the quinone group of the drugs with �-cyclodextrin. CV studies indicate that the process is irreversible and adsorption-controlled. The experimental parameters which influence the peak current responses of OF, NF, GF, and LF were studied. The reduction peak currents of OF, NF, GF, and LF change linearly over the common concentration range from 3.2 � 10-8 to 2 � 10-5 M, with a common correlation coefficient and limit of detection of 0.9995 and 2.4 � 10-8 M, respectively, in pH 4.0 Britton-Robinson (BR) buffer at an accumulation time of 160 s. The interference of metal ions in the peak current response was also studied. The modified electrode exhibited good sensitivity and stability. The proposed method was applied to the determination of OF, NF, GF, and LF in both commercially available drugs and spiked human urine samples.
ACCESSION #
23894920

 

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